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Unformatted text preview: BIO201 Final Exam Review Lecture 30 Cell Cycle Arrest- Detect DNA damage or cellular abnormalities and stalls progression to next step- During the delay, DNA damage is repaired or cell defect is corrected- Three main checkpoints are at: 1) G1 , 2) G2 , 3) Mitosis DNA Content and Ploidy- Haploid: Single set of genetic information. Single Genome- Diploid: Two full sets of genetic information. Two copies of genome- Polyploidy: Many sets of genetic information. Many genomic copies- Ploidy(n): number of sets of genetic information. Number of copies of the genome- X: Mass of DNA or amount of DNA- C: Number of base pairs (size of DNA) Human DNA Content during Cell Cycle- G1: 22 autosomes + 1 sex chromosome (23 kinds of disperse chromatin) o 46 pieces of disperse chromatin . Linear and double stranded diploid (2n)- S: each pieces doubles o 92 pieces of disperse chromatin diploid (2n)- G2: same as S phase o 92 pieces of disperse chromatin diploid (2n)- Mitosis: 92 pieces of disperse G2 chromatin condenses to 92 chromatids o 92 chromatids are paired into 46 mitotic chromosomes diploid (2n) Lecture 31 DNA changes during Cell Cycle- G1 phase ( diploid ; 2n) o All DNA is disperse . Transcription and translation can happen. o 23 strands of paternal + 23 strands of maternal = 46 strands of disperse chromatin o 2n2x2c - S phase ( diploid ; 2n) o Replication. Disperse chromatin doublesReplication....
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