Final Exam2005

Final Exam2005 - Final Exam, BIO201B, 2005 Form 1 Name_...

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Final Exam, BIO201B, 2005 Form 1 Name_______________________________ Each question has only one right answer. Choose the best answer for each. 1. Which of the following best describes what happens in human mitotic prophase? A. The spindle forms, DNA condenses and mitotic chromosomes are seen as paired sister chromatids B. Homologous chromosomes pair (attached at their centromeres by synaptonemal complexes) and the nuclear membrane breaks down C. The cell goes from 2n2x2c to 2n4x4c as chromatids pair up and chromosomal microtubules begin to make contact with kinetochores D. Chromatin compaction enables sister chromatids to pair and arrange in syntelic orientation, the ER and golgi break down and microtubules begin to grow out from the centrioles E. Mitotic chromosomes begin to move toward the spindle equator, held together by condensin, compactin and chiasmata 2. Which of the following does not occur in rough endoplasmic reticulum? A. Synthesis of soluble proteins B. Addition of core carbohydrates to proteins C. Glycosylation of lipids D. Steroid hormone synthesis E. Phospholipid synthesis 3. If two types of large particles have the same densities but very different S values: A. They can’t be separated by centrifugation but could be separated by polyacrylamide electrophoresis B. They can be separated by density gradient centrifugation but not by differential centrifugation C. They can be separated by homogenization D. It is more likely that they would be separated by differential centrifugation than by density centrifugation E. They can’t be separated at all because they have the same densities 4. The first 15-20 amino acids of a nascent peptide on soluble, cytoplasmic, eukaryotic polysomes are most like to be needed to determine each of the following except : A. Whether the mature protein will remain in the cytoplasm B. Whether the mature protein will go to the nucleus C. Whether the mature protein will end up inside the mitochondria D. Whether the translation will be completed in the cytoplasm or be directed to continue on RER E. Whether an integral membrane protein is a spanning protein or not 5. Which of the following could be part of RER membranes but not golgi membranes? A. Transmembrane cargo receptors B. SRP receptors C. Integral membrane proteins D. COPI E. Glycolipids 1
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6. A nascent protein in the RER that is destined to be a soluble enzyme inside of lysosomes should have: A. No NLS, signal sequence or stop transfer sequence, just a mannose-6- phosphate B. A low pH optimum and clathrin on the outside of the vesicle as it leaves the RER C. Problems getting there because it should be made on free polysomes, not on RER D. A signal sequence and the ability to accept a mannose-6-phosphate modification but no NLS or stop transfer sequences E. An LLS (lysosome localization sequence) but no stop transfer sequence or signal sequence 7. Which of the following is most likely to be made by co-translational translocation? A.
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Final Exam2005 - Final Exam, BIO201B, 2005 Form 1 Name_...

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