1 - History of Virology 1892 Discovery of the first virus...

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History of Virology 1892 Discovery of the first virus (Dimitrii Ivanowsky, Russian) Tobacco mosaic disease is caused by a distinctive agent so small that it could pass through filters that trapped all known bacteria. 1898 Extracts of an infected tobacco plant diluted into sterile solution produced no additional infectious agents until introduced into leaves of healthy plant. Serial transmission of the disease. (Beijerinck, Holland) "Virus" in Latin "Poison". 1898 Causative agent of FMD was also filterable. (Loeffler & Frosch, German) 1901 Identification of first human virus (Yellow fever virus). (Walter Reed, USA) Identification of mosquitoes as vector of yellow fever virus. 1908 Identification of virus that caused Leukemias in chicken. (Ellerman & Bang) 1915 Discovery of bacteriophage (Frederick Twork). "Phage" in Latin "Eating". 1933 Discovery of influenza 1934 Crystal of TMV was obtained and confirmed the structural simplicity of virus (Wendell Stanley).
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Definition/Characteristics of Virus 1. A virus is a very small, infectious, intracellular parasite. 2. The virus genome comprises of either DNA or RNA. 3. Within its host cell, the virus genome is replicated and directs the synthesis of other virion components. 4. It lacks the complex energy-generating and biosynthetic systems. 5. Progeny virions are formed by de novo assembly from newly synthesized components within the host cells. 6. A progeny virion is a vehicle for transmission of the viral genome to the next host cell. 7. Virus does not have motor unit.
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In the latest report of the International Committee on Taxonomy of Viruses (ICTV), approximately 4000 viruses (animal, plant, bacteria) have been assigned to one of 71 families, subfamilies, and 164 genera. Viruses can be classified by
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This note was uploaded on 10/02/2010 for the course BIO 100 taught by Professor Lam during the Spring '10 term at Hong Kong Institute of Vocational Education.

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1 - History of Virology 1892 Discovery of the first virus...

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