Lecture 2 Resting Membrane Potential 10 web

Lecture 2 Resting Membrane Potential 10 web - Cell Biology...

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Cell Biology & Neuroscience 146:245 -Prof. Sidney Auerbach- course coordinator Nelson Labs D410, Busch Campus auerbach@biology.rutgers.edu Office hours: Mon & Wed after class (or by appointment) - ourse Web Site: Sakai Cou se eb S te Sa a https://sakai.rutgers.edu
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tudy Groups Study Groups • Professor Charles Page will lead one study group session each week • Meeting time: – Wednesday mornings: 10:15 – 11:15 – Room 336 MSLC, ARC Bldg Busch Campus – Beginning September 15th
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The Resting Membrane Potential Chapter 3
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lectrical Signals in Nerve Cells Electrical Signals in Nerve Cells formation transmitted b ithin • Information transmitted by __________ within neurons ignaling involves : ovement of • Signaling involves _________: movement of ____ across cell membrane ignaling is but much ompared to electric signaling is ____ but much _____ compared to electric current in wires
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Ionic concentration of biological fluids • Ion = atom or molecule with an ___________________ • Neurons are bathed in ________________containing a Cl K nd Ca + mong others) Na + , Cl - , K + and Ca 2+ (among others) • Intracellular fluid also contains these ions but in different _____________ plus a relatively high concentration of charged organic substances (amino acids, sugars, proteins nucleic acids etc.) * Note that organic substances account for electroneutrality and osmotic balance
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Ions cannot freely cross plasma membrane • Cells encased by ________________: ‘plasma membrane’ isolates side of cells from ________________isolates inside of cells from extracellular fluid
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Ions diffuse across membrane via ion channels • Ion channels are ______ that ____ the membrane: • 4-6 subunits forming a central _____ • ___________: type of subunits determines which ion(s) can pass g K elective channels – e.g. K + selective channels + selective channels n channels increase Ion channels increase membrane permeability
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Ionic current depends on membrane 1. Electrons: ____________ i = V/R (i: current; V: voltage; R: resistance) or restated i=±V± x g (g: conductance = 1/R) : ux [force on ion] 2. _____: flux = [force on ion] x Permeabilit y note: ‘P’ is membrane permeability; analogous to conductance) Two ______ regulate ion movement across cell membrane: lectrical (voltage) 1. Electrical (voltage) 2. Chemical (concentration difference)
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Chemical ‘force’ • _______ acts to distribute ions evenly in a solution – _____________-dependent _______ movement of ions in solution in water: ______ (NOT bulk flow) – Net movement of solute om regions of high from regions of high concentration to regions of low concentration
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Electrical force ns are charged: Ions are charged: Thus _______________also move ions membrane dividing solutions in two compartments When channels inserted in membrane, ions move according to their electrical charge
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Lecture 2 Resting Membrane Potential 10 web - Cell Biology...

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