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Lecture 2 Resting Membrane Potential 10 web

Lecture 2 Resting Membrane Potential 10 web - Cell Biology...

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Click to edit Master subtitle style Cell Biology & Neuroscience 146:245 -Prof. Sidney Auerbach- course coordinator Nelson Labs D410, Busch Campus [email protected] Office hours: Mon & Wed after class (or by appointment) - Course Web Site: Sakai https://sakai.rutgers.edu
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Study Groups Professor Charles Page will lead one study group session each week Meeting time: Wednesday mornings: 10:15 – 11:15 Room 336 MSLC, ARC Bldg Busch Campus Beginning September 15th
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Click to edit Master subtitle style The Resting Membrane Potential Chapter 3
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Electrical Signals in Nerve Cells Information transmitted by __________ within neurons Signaling involves _________: movement of ____ across cell membrane signaling is ____ but much _____ compared to electric current in wires
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Ionic concentration of biological fluids Ion = atom or molecule with an ___________________ Neurons are bathed in ________________containing Na+, Cl-, K+ and Ca2+ (among others) Intracellular fluid also contains these ions but in different _____________ plus a relatively high concentration of charged organic substances (amino acids, sugars, proteins nucleic acids etc.) * Note that organic substances account for electroneutrality and osmotic balance
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Ions cannot freely cross plasma membrane Cells encased by ________________: ‘plasma membrane’ ________________isolates inside of cells from extracellular fluid
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Ions diffuse across membrane via ion channels Ion channels are ______ that ____ the membrane: 4-6 subunits forming a central _____ ___________: type of subunits determines which ion(s) can pass e.g. K+ selective channels & Na+ selective channels Ion channels increase membrane permeability
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Ionic current depends on membrane conductance & force on an ion 1. Electrons: ____________ i = V/R (i: current; V: voltage; R: resistance) or restated i = V x g (g: conductance = 1/R) 2. _____: flux = [force on ion] x Permeabilit y note: ‘P’ is membrane permeability; analogous to conductance) Two ______ regulate ion movement across cell membrane: 1. Electrical (voltage) 2. Chemical (concentration difference)
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Chemical ‘force’ _______ acts to distribute ions evenly in a solution _____________-dependent _______ movement of ions in solution in water: ______ (NOT bulk flow) Net movement of solute from regions of high concentration to regions of low concentration
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Electrical force Ions are charged: Thus _______________also move ions membrane dividing solutions in two compartments When channels inserted in membrane, ions move according to their electrical charge
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