Lecture 3 Action Potential _10 web

Lecture 3 Action Potential _10 web - Resting Membrane...

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Resting Membrane Potential ontinued) (continued) & The Action Potential Chapters 3 & 4
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First Quiz The first quiz posted on Sakai: 10 multiple choice questions Submit on-line by 10 PM Friday, Sept. 17 Each quiz will equal 2 points 10 quizzes during the semester together equaling 20 points: 10% of your final grade You can skip 3 quizzes without penalty other than losing 2 pq p y g points for each quiz. However, if you miss more than 3 quizzes , your quiz score for the semester will be ZERO
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tudy Group Study Group Professor Charles Page – Meeting time: • Wednesday mornings: 10:15 – 11:15 • Room 336 MSLC, ARC Bldg Busch Campus • Beginning this week: September 15 th
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Text book • Neuroscience Exploring the Brain, rd dition Bear Connors & aradiso 3 edition, Bear, Connors & Paradiso *** You are responsible (on tests) ONLY for the xt book chapters & sections covered in class text book chapters & sections covered in class • 2nd edition is ok; supplemental material with ew copies is OT ssential new copies is NOT essential • Text book will be placed on reserve in the LSM ibrary of Science & Medicine; Busch Campus) (Library of Science & Medicine; Busch Campus) but this may take several days to a week
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Resting Membrane Potential (RMP) According to Nernst: E ion 61.5 mV z log [ion] outside [ion] inside = • if plasma membrane was: permeable only to K + ; RMP would equal E K -80 mV when K + gradient = 1/20 [inside/outside] Assuming constant [K + ] i = 100 mM Nernst predicts Vm = Measured changes in Vm in response to altering [K+] o 0 mV when [K + ] o = 100 mM -61.5 mV when [K + ] o = 10 mM measured Vm predicted by Nernst theory -123 mV when [K + ] o = 1 mM of easured m not as -120 _________of measured Vm is not as ______ as predicted by Nernst theory
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esting Membrane Potential MP) Resting Membrane Potential (RMP) • RMP of a typical neuron is -65 mV, because the membrane at rest is much more permeable to K + , but also a little permeable to Na + • The _________ equation calculates RMP using relative ermeability of the membrane to different ions permeability of the membrane to different ions 1 5 mV g P K [K] out P Na [Na] out + V = 61.5 mV log P K [K] in P Na [Na] in +
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] a] V = 61.5 mV log P K [K] out P K [K] in P Na [Na] out P Na [Na] in + + Goldman equation gives a resting membrane potential of -65 mV if the cell membrane is 40 times more permeable to K + than Na + = 1.5 mV g 40 (5) + 1 (150) V 61.5 mV log 40 (100) + 1 (15) = 1 5 mV g 50 61.5 mV V log 350 4015 = -65 mV
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hannels ____ channels • Plasma membrane permeability to each ion depends on the number of open ion channels for that ion. • The plasma membrane is much more permeable to K + than Na + because at rest many more potassium channels are open relative to sodium channels (and channels for other ions).
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This note was uploaded on 10/03/2010 for the course RUT 146:356 taught by Professor Gol during the Spring '10 term at Rutgers.

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Lecture 3 Action Potential _10 web - Resting Membrane...

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