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Lecture 3 Action Potential _10 web

Lecture 3 Action Potential _10 web - Resting Membrane...

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Click to edit Master subtitle style Resting Membrane Potential (continued) & Chapters 3 & 4
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First Quiz The first quiz posted on Sakai: 10 multiple choice questions Submit on-line by 10 PM Friday, Sept. 17 Each quiz will equal 2 points 10 quizzes during the semester together equaling 20 points: 10% of your final grade You can skip 3 quizzes without penalty other than losing 2 points for each quiz. However, if you miss more than 3 quizzes , your quiz score for the semester will be ZERO
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Study Group Professor Charles Page Meeting time: Wednesday mornings: 10:15 – 11:15 Room 336 MSLC, ARC Bldg Busch Campus Beginning this week: September 15th
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Text book Neuroscience Exploring the Brain, 3rd edition, Bear, Connors & Paradiso *** You are responsible (on tests) ONLY for the text book chapters & sections covered in class 2nd edition is ok; supplemental material with new copies is NOT essential Text book will be placed on reserve in the LSM (Library of Science & Medicine; Busch Campus) but this may take several days to a week
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Resting Membrane Potential (RMP) According to Nernst: if plasma membrane was: permeable only to K+; RMP would equal EK -80 mV when K+ gradient = 1/20 [inside/outside] Eion 61.5 mV z log [ion]ou tside [ion]insi de = Vm predicted by Nernst theory -120 Assuming constant [K+] i = 100 mM Nernst predicts Vm = 0 mV when [K+] o = 100 mM -61.5 mV when [K+] o = 10 mM -123 mV when [K+] o = 1 mM _________of measured Vm is not as ______ as predicted by Nernst theory Measured changes in Vm in response to altering [K+] o measured
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Resting Membrane Potential (RMP) RMP of a typical neuron is -65 mV, because the membrane at rest is much more permeable to K+, but also a little permeable to Na+ The _________ equation calculates RMP using relative permeability of the membrane to different ions V = 61.5 mV log P K [K]ou t P K [K]in P Na [Na]o ut P Na [Na]i n + +
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Goldman equation gives a resting membrane potential of -65 mV if the cell membrane is 40 times more permeable to K+ than Na+ V = 61.5 mV log P K [K]ou t P K [K]in P N a [Na]o ut P N a [Na]i n + + V = 61.5 mV log 40 (5) + 1 (150) 40 (100) + 1 (15) = 61.5 mV V log 350 4015 = -65 mV
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____ channels Plasma membrane permeability to each ion depends on the number of open ion channels for that ion. The plasma membrane is much more permeable to K+ than Na+ because at rest many more potassium channels are open relative to sodium channels (and channels for other ions).
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