Lecture 7 Neurotransmitter control of behavior web

Lecture 7 Neurotransmitter control of behavior web - Exam I...

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Exam I Monday October 4th, in class PH 111, 1:40 – 3:00 PM 50 multiple choice questions – No calculators needed uestions are from lecture material; the text book is a Questions are from lecture material; the text book is a good supplement but topics in the book that are not covered in class, will NOT be tested alid, verifiable excuse to take a make- p exam: Valid, verifiable excuse to take a make up exam: • Make-up exam: short answer / essay style questions – If you miss the exam and do not have a valid excuse, ou will receive a zero on the exam. This will count y toward your final grade in the class.
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Neurotransmitter Systems Chapter 6 Chemical Control of Behavior hapter 15: 482 83 490 07 Chapter 15: 482-483, 490-507 Chapter 17: 543 – 545
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Patterns of Communication in the CNS • Transmitters acting at _________receptors usually • Transmitters acting at ___________ receptors are leased by neurons with convey ________information in a ‘point to point’ manner xample: pressure sensitive released by neurons with highly branched axons that ________ neuronal activity Example: pressure sensitive sensory neurons that stimulate release of lutamate in omatotopic in divergent areas and thus regulate behavioral _____ xample: erotonergic glutamate in somatotopic ‘map’ of body surface in somatosensory (‘touch’) area Example: serotonergic soma in brainstem raphe innervating most areas of of cerebral cortex CNS to influence state of consciousness
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G-protein coupled receptors (GPCRs) • Single protein with _ membrane spanning domains ‘Superfamily’: all with ____ basic structure
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GPCRs: Function GPCRs mediate slower, longer-lasting, effects examples: β -adrenergic (NE) and muscarinic (ACh) on _____ equence of events Sequence of events 1. Neurotransmitter binds to receptor. 2. Receptor activates G-protein 3. Activated G-protein stimulates (or inhibits) effector proteins: Effector proteins can be (a) ion channels or (b) enzymes that generate _____________________
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Synaptic modulation alters neuronal excitability Norepinephrine (NE) influences K + channels through β receptors – NE binding of to β adrenergic receptor activates Gs, that in turn activates adenylyl cyclase, resulting in increased cAMP levels then activation of rotein inase & thus hosphorylation f K ak channels protein kinase A & thus phosphorylation of K + leak channels – Phosphorylated potassium channels close, decreasing the K + conductance and increasing cell excitability: heart beats faster ACh binding to muscarinic receptor activates & has gp __ ________ effect: heart beats more slowly ‘Gs’
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Two Examples of Modulation in CNS V x = V o /e x/ λ Spontaneous burst mode λ α r m / r i via GPCR shuts “pacemaker channels” Evoked single spike mode When phosphorylation closes some ______channels, efficacy
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Lecture 7 Neurotransmitter control of behavior web - Exam I...

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