Lecture 7 Neurotransmitter control of behavior web

Lecture 7 Neurotransmitter control of behavior web - Exam I...

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Exam I Monday October 4th, in class PH 111, 1:40 – 3:00 PM 50 multiple choice questions No calculators needed Questions are from lecture material; the text book is a good supplement but topics in the book that are not covered in class, will NOT be tested Valid, verifiable excuse to take a make-up exam: Make-up exam: short answer / essay style questions If you miss the exam and do not have a valid excuse, you will receive a zero on the exam. This will count
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Click to edit Master subtitle style Neurotransmitter Systems Chapter 6 Chemical Control of Behavior Chapter 15: 482-483, 490-507 Chapter 17: 543 – 545
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Patterns of Communication in the CNS Transmitters acting at _________receptors usually convey ________information in a ‘point to point’ manner Example: pressure sensitive sensory neurons that stimulate release of glutamate in somatotopic ‘map’ of body surface in somatosensory (‘touch’) area of cerebral cortex Transmitters acting at ___________ receptors are released by neurons with highly branched axons that ________ neuronal activity in divergent areas and thus regulate behavioral _____ Example: serotonergic soma in brainstem raphe innervating most areas of CNS to influence state of consciousness
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G-protein coupled receptors (GPCRs) Single protein with _ membrane spanning domains ‘Superfamily’: all with ____ basic structure
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GPCRs: Function GPCRs mediate slower, longer-lasting, effects examples: β-adrenergic (NE) and muscarinic (ACh) on _____ Sequence of events 1. Neurotransmitter binds to receptor. 2. Receptor activates G-protein 3. Activated G-protein stimulates (or inhibits) effector proteins: Effector proteins can be (a) ion channels or (b) enzymes that generate _____________________
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Synaptic modulation alters neuronal excitability Norepinephrine (NE) influences K+ channels through β receptors NE binding of to β adrenergic receptor activates Gs, that in turn activates adenylyl cyclase, resulting in increased cAMP levels then activation of Phosphorylated potassium channels close, decreasing the K+ conductance and increasing cell excitability: heart beats faster ACh binding to muscarinic receptor activates __ & has ________ effect: heart beats more slowly ‘Gs’
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Two Examples of Modulation in CNS When phosphorylation closes some
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Lecture 7 Neurotransmitter control of behavior web - Exam I...

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