vasopressin_20receptors_20in_20humans_20PNAS

vasopressin_20receptors_20in_20humans_20PNAS - Genetic...

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Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans Hasse Walum* †‡ , Lars Westberg †§ , Susanne Henningsson § , Jenae M. Neiderhiser , David Reiss i , Wilmar Igl*, Jody M. Ganiban**, Erica L. Spotts †† , Nancy L. Pedersen*, Elias Eriksson § , and Paul Lichtenstein* *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, S-171 77 Stockholm, Sweden; § Department of Pharmacology, Institute of Neuroscience and Physiology, University of Gothenburg, Box 431, S 405 30 Gothenburg, Sweden; Department of Psychology, Pennsylvania State University, University Park, PA 16802; i Yale Child Study Center, Yale University, New Haven, CT 06520; **Department of Psychology, The George Washington University, Building GG 2125 G St NW, Washington, DC 20052; and †† Behavioral and Social Research Program, National Institute on Aging, Bethesda, MD 20892-9205 Edited by Solomon H. Snyder, Johns Hopkins University School of Medicine, Baltimore, MD, and approved July 14, 2008 (received for review March 28, 2008) Pair-bonding has been suggested to be a critical factor in the evolutionary development of the social brain. The brain neuropep- tide arginine vasopressin (AVP) exerts an important inFuence on pair-bonding behavior in voles. There is a strong association between a polymorphic repeat sequence in the 5 * Fanking region of the gene ( avpr1a ) encoding one of the AVP receptor subtypes (V1aR), and proneness for monogamous behavior in males of this species. It is not yet known whether similar mechanisms are important also for human pair-bonding. Here, we report an asso- ciation between one of the human AVPR1A repeat polymorphisms (RS3) and traits reFecting pair-bonding behavior in men, including partner bonding, perceived marital problems, and marital status, and show that the RS3 genotype of the males also affects marital quality as perceived by their spouses. These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized inFuence of AVP on pair-bonding in voles may be of relevance also for humans. monogamy u neuropeptide u polymorphism u social behavior P rimate social organization is often characterized by bonded relationships, and recent analyses suggest that it may have been the particular demands for pair-bonding behavior that triggered the evolutionary development of the primate social brain (1). The brain neuropeptide arginine vasopressin (AVP), acting through the re- ceptor subtype V1aR, plays a key role in the regulation of pair- bonding behavior in male rodents, as revealed by a series of elegant studies on closely related vole species, i.e., montane voles ( Microtus montanus ), meadow voles ( Microtus pennsylvanicus ), and prairie voles ( Microtus ochrogaster ) (2). In prairie voles, which in contrast to montane and meadow voles are socially monogamous and highly social, pair-bond formation and related behaviors are facilitated by AVP and prevented by a V1aR antagonist (3). Supporting the
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This note was uploaded on 10/03/2010 for the course RUT 146:356 taught by Professor Gol during the Spring '10 term at Rutgers.

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vasopressin_20receptors_20in_20humans_20PNAS - Genetic...

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