Chapter 4 part 3 - Chapter 4 (part 3) How does the...

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Chapter 4 (part 3) How does the structure of a protein affect its biological function?
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Animal Scrapie : s he e p  TME  (tra ns m is s ib le  m ink e nc e pha lo pa thy): m ink  CWD  (c hro nic  wa s ting  dis e a s e ): m ule de e r, e lk  BSE  (b o vine  s po ng ifo rm  e nc e pha lo pa thy): c o ws Human CJD : C re utzfe ld-Ja c o b  Dis e a s e   FFI : Fa ta l fa m ilia l Ins o m nia   Kuru incurable degenerative neurological disorder (brain disease) that is a type of transmissible spongiform encephalopathy found in humans. It is caused by a misfolded protein called a prion.
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PrPC PrPSc solubility soluble non soluble structure predominantly alpha-helical predominantly beta-sheeted multimerisatio n state monomeric multimeric (aggregates) infectivity non infectious infectious
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Collagen Ma jo r pro te in c o m po ne nt o f c o nne c tive  tis s ue - 25-35%  o f the  pro te in c o nte nt in m a m m a ls -  te ndo ns , s tiff ro pe like  fib e rs -  s kin, lo o s e ly wo o ve n fib e rs 3 le ft-ha nde d he lic a l c ha ins  c o ile d a ro und e a c h o the r in a  rig ht ha nde d s upe rc o il. 3AA pe r turn, ris e  0.31 pe r re s idue , 0.94 nm  pitc h pe r turn…m o re e xte nde d tha t a n  α -he lix….tig hte r he lix tha n a n  α -he lix. O fte n fine  G ly-X-Y   X o fte n pro line , Y o fte n 4-hydro xypro line No  intra c ha in H-b o nds , o nly inte rm o le c ula r H-b o nds S o m e wha t o f a  hyb rid b e twe e n a n  α -he lix a nd a   β -s tra nd.
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Collagen Bundle of 3 peptide chains in a coil
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The structure of collagen fibers.
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Stabilized by inter- molecular hydrogen bonds Presence of glycine and proline residues makes chain rigid and incapable of forming an  α- helix. Allows tighter formation of a coil.
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and 5-hydroxylysine 4-hydroxyproline 5-hydroxylysine N H CH C CH 2 O CH 2 HC CH 2 NH 3 + OH Hydroxyl group often connected to a carbohydrate to make a glycoprotein…role of carbohydrate not  known. Hydroxylation occurs after peptide synthesis…need Ascorbic acid (vitamin A) to occur. People deprived of vitamin A develop scurvy. Symptoms = skin leasions, fragile blood vessels, loose teeth, bleeding gums…
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This note was uploaded on 10/03/2010 for the course CHEM 527 taught by Professor Starnes,s during the Fall '08 term at Texas A&M University–Commerce.

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Chapter 4 part 3 - Chapter 4 (part 3) How does the...

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