BIS 104 Final Summer I 2006

BIS 104 Final Summer I 2006 - BIS 104 Summer I 2006 Final-...

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View Full Document Right Arrow Icon SSI 2006 PART I: Fill in the blank with the term that best fits the definition. Be as specific as possible. Established abbreviations or acronyms may be used. (10 pts) -The motor protein that transports cargo in the minus (-) direction along microtubules dynein -Term used to describe the ability of a microscope to discriminate between two neighboring points in a specimen. Resolution -A protein that spans the lipid bilayer and has both an external and an internal domain in the plasma membrane. Integral protein or transmembrane protein -The movement of small molecular weight molecules (solutes) across the plasma membrane without the aid of proteins or the expenditure of energy. Simple diffusion -The specific process by which LDLs (low density lipoproteins) are internalized by cells. Receptor mediated endocytosis (RME) -The family of intermediate filaments (IFs) that is associated exclusively with Schwann and glial cells Glial fibrillary acidic protein (GFAP) -Special sub-domains with a plasma membrane that are rich in cholesterol sphingolipids and protein Lipid rafts -The technique that allows you to examine the inner surface of both the inner and outer leaflets of a lipid bilayer. Freeze fracture -The term used to describe a transporter protein that moves two different solutes in the same direction at the same time. symporter 2. For each of the items listed below, describe: (8 pts) i) its composition and location in the cell ii) its function A) Signal recognition Particle (SRP) i) A complex of proteins and a single RNA species found in the cytoplasm, or attached to RER translocon if synthesis of a secretory protein is in progress. ii) Recognizes and binds to the Rbs / mRNA / nascent polypeptide complex if a signal sequence is present. SRP binds to its complex and attaches to the translocon / SRP receptor on the ER. B) Golgi Complex i) Series of disk-like flattened membrane cisternae and tubules with associated vesicles. Usually oriented adjacent to one side of the nucleus (perinuclear). ii) Composed of functionally distinct compartments (CGN, MGN, TGN) where proteins are sorted, processed and packaged for transport to specific intracellular destinations. PART II 3. How is the protein ubiquitin involved in the regulation of the cell cycle? (4 pts) The availability of cyclin proteins in required for the activation of the cdk cell cycle engine. The half-life of cyclin proteins is regulated by the attachment of ubiquitin molecules that mark them for degradation. Therefore, one level of cell cycle control depends on the balance of synthesis and degradation of cyclins. 4. What is the relationship between ubiquitins and proteasomes? (4 pts)
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This note was uploaded on 10/04/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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BIS 104 Final Summer I 2006 - BIS 104 Summer I 2006 Final-...

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