This preview shows pages 1–2. Sign up to view the full content.
This preview has intentionally blurred sections. Sign up to view the full version.View Full Document
Unformatted text preview: 2 CH 3 O H 2 N-NH 2 NaOH (excess) HONO N CO 2 H N O 30-Propose a multistep synthesis to carry out the transformation below (~6 steps): 1- Mg, CO 2 2- DCC, DMAP, (CH 3 ) 2 NH 3- HF (deprotects both at once) 4- CH 3 COCl 5- PhNH 2 followed by NaCNBH 3 Other answers are possible 031-Propose a multistep synthesis to carry out the transformation below (~8 steps): 1-H 2 , Pt 2-HONO 3-NaCN 4-H + or NaOH (CN COOH) 5-PBr 3 (excess, to form acid bromide and alpha-bromo-ketone) 6-PhCH 2 OH (ester formation) 7-H + (elimination of alpha-bromo) 8-CH 3 CH 2 CH 2 ONa to do Michael addition Other answers are possible....
View Full Document
- Spring '06
- molecular biology