Anxiolytics2009

Anxiolytics2009 - MEDC 417/502 Dr. McCurdy ANXIOLYTIC...

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MEDC 417/502 Dr. McCurdy ANXIOLYTIC AGENTS Medicinal Chemistry of Treatments for Anxiety Disorders Anxiety and Anxiety Disorders Anxiety = a sense of apprehensive expectation DSM-IV-RT classification Interferes with normal social or occupational functioning Must not be caused by and exogenous factor or a medical condition Examples of Anxiety Disorders Specific phobias Generalized anxiety disorder Social phobia Obsessive compulsive disorder Panic disorder Post-traumatic stress disorder Etiology of Anxiety Disorders No known neuroanatomical lesions Altered ___________________ or utilization of ____________ in the hippocampus (and other limbic areas) and the prefrontal cortex Variety of neurotransmitters, neuromodulators, and neuropeptides are suggested Abundant evidence to document ________, ____________, and ______________ GABA/BDZ Receptor Complex GABA ______________________________________ Approximately __________ of all synapses in the CNS utilize GABA Two classes of GABA receptors:
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MEDC 417/502 Dr. McCurdy GABA A has a number of _______________________ for neuroactive drugs. GABA RECEPTOR Three Major BDZ Binding Sites BDZ 1 - Predominantly in the ____________ - Interaction leads to ______________ sedatives BDZ 2 - In cortex, hippocampus and spinal cord - Interaction leads to ____________ anxiolytics - May be involved in cognition, memory BDZ 3 - Located ________________ - Not involved in _______________efficacy Drugs used in the treatment of anxiety Benzodiazepines (BDZs) Nonbenzodiazepine agonists GABA re-uptake inhibitors Serotonin receptor agents Serotonin re-uptake inhibitors (SSRIs)
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Anxiolytics2009 - MEDC 417/502 Dr. McCurdy ANXIOLYTIC...

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