Exam 4 - Cell Biology / Cell Biochemistry BIOL 4374 / BCHS...

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Cell Biology / Cell Biochemistry BIOL 4374 / BCHS 4313 Exam 4 May 4, 2009 Read each question carefully . Chose the single best answer to each of the following questions. In some cases, key words are emphasized in bold italics font 1. The substance in the cytoplasm of M-phase cells that promotes mitosis in cell-free extracts of Xenopus oocytes was originally called . .. a. Mitosis Promoting Factor b. Maturation Promoting Factor c. Mammalian Prometaphase Factor d. Maternal Procreation Factor e. Momma’s Powerful Force 2. MPF activity is attributed to which of the following proteins? a. cyclin dependent kinase 1 (Cdk1) b. cyclin dependent kinase 2 (Cdk2) c. cyclin A d. cyclin B e. MPF is not a protein 3. In rapidly dividing cells, MPF activity was observed to oscillate, with peak levels occurring at the G2 – M transition. The oscillatory component of the MPF complex was later shown to be which of the following proteins? a. cyclin dependent kinase 1 (Cdk1) b. cyclin dependent kinase 2 (Cdk2) c. cyclin A d. cyclin B e. Like I told you in my response to the last question … MPF is not a protein! 4. Which of the following enzymes is responsible for the reversible inhibition of M-Cdk? a. Wee1 kinase b. Polo kinase c. cdc25 phosphatase d. S-Cdk e. none of the above 5. What is p27? a. a component of the pre-initiation complex b. a Cdk inhibitor c. a component of APC d. the page between p26 and p28 e. none of the above
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6. S-Cdk complex prevents multiple DNA replication events by phosphorylating which of the following? a. M-Cdk b. cdc6 [note: phosphorylation of this protein initiates DNA replication] c. origin of replication complex d. p21 e. none of the above 7. The SMC protein complexes that gather and organize DNA strands into chromosomes are called … a. gatherins b. cohesins c. compactins d. condensins e. none of the above 8. All of the following proteins are phosphorylated by M-Cdk, except a lamins b. cdc25 c. cohesins d. APC e. all are phosphorylated by M-Cdk 9. Breakdown of the nuclear envelop occurs during which phase of mitosis? a. prophase b. prometaphase c. metaphase d. anaphase e. telophase 10. At the anaphase checkpoint , which of the following events must occur for mitosis to proceed? a. ubiquination of cyclin B by APC b. phosphorylation of cdc25 c. activation of p53 d. dephosphorylation of M-Cdk e. none of the above 11. Which event triggers chromosomal segregation? a. ubiquination of cyclin B by APC b. degradation of cyclin B c. degradation of cdk1 d. proteolytic cleavage of cohesins by separase e. activation of kinesin motors
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12. The minus (-) end directed motor proteins that pull the spindle poles toward the plasma membrane are called … a. kinesin 14 b. kinesin 5 c. kinesin 4/10 d. dynein e. myosin I 13. During anaphase, the forces that drive movement of chromatids toward opposite spindle poles include all of the following except a. plus end depolymerization of kinetochore microtubules
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This note was uploaded on 10/05/2010 for the course BCHS 3305 taught by Professor Briggs during the Spring '10 term at University of Houston-Victoria.

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Exam 4 - Cell Biology / Cell Biochemistry BIOL 4374 / BCHS...

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