BIS2A. Study questions 9 1. A pathogen of bees produces a protein that enters the cell of the host, migrates further into mitochondria and lodges itself in the inner membrane of the mitochondrion. The protein forms a channel that allows H+ to move across the membrane according to the proton gra-dient. Using your knowledge of cellular processes predict the effects caused by this protein in the short and longer range. The pathogen protein short-circuits the Proton Motive Force that is supposed to generate ATP by flowing through the ATP synthase protein. The energy accumulated in the proton gradient is re-leased as heat and no ATP is made. In the short range, the muscles of the bee can function anaer-obically. In the long range, the lack of ATP synthesis in the mitochondrion is equivalent to suffo-cation due to lack of O2 and the bee will die. 2. Suppose that a bee is Fying in a anaerobic mode when this protein is made and exerts its ef-fects. What will happen in the very short range?
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