biosignaling - pp 458-468 Some things to consider while...

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BC368 – Biochemistry of the Cell II Biosignaling Topics: Overview of signaling pp. 437-441 ion channels as signal receptors pp. 441-445 + Chap. 12 steroid hormones and their receptors pp. 468-469 the three major classes of membrane receptors 2nd messengers and their general functions cAMP as a 2nd messenger pp. 449-455, 466 G-protein coupled receptors G-proteins adenylyl cyclase cAMP protein kinases and PKA IP 3 , DAG, and Ca 2+ as 2nd messengers pp. 456-458 phospholipase C activation PIP breakdown yields DAG and IP 3 IP 3 triggers Ca 2+ release from internal stores calmodulin DAG and protein kinase C cGMP pp. 448-449 Receptor tyrosine kinases pp. 445-448 autophosphorylation Ras protein genetic studies: sevenless mutants and picking apart the pathway MAP kinase pathways Regulation and integration of multiple signaling pathways
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Unformatted text preview: pp. 458-468 ____________________________________ Some things to consider while you’re reading: 1. We’ll spend a fair amount of time talking about how external signals are transduced into signals inside the cell. But how important is it to turn all those signals off? 2. How fast are the cells’ responses to external signals? What are the rate limiting steps? 3. What determines whether or not a cell responds to a particular signal? 4. How come we don’t see much about signaling in plants? Are they different, or are they just more difficult to study? 5. How does a cell integrate all of this information? Are there “local” responses? In other words, can there be multiple responses going on in a cell at one time?...
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