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Ch23 - B C 368 Bi ochemi str y of the Cel l I I I ntegr ati...

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BC 368 Biochemistry of the Cell II Integration of Mammalian Metabolism Highlights of Ch 23 May 6, 2010
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Highlights of Metabolism 1. ATP = universal energy currency expended to ensure unidirectionality of each metabolic pathway and complete conversion to products coupling ATP hydrolysis to a reaction increases K by a factor of ~10 8 .
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1. ATP = universal energy currency expended to ensure unidirectionality of each metabolic pathway and complete conversion to products an important allosteric regulator generated by the oxidation of fuel molecules: NADH and FADH 2 shuttle electrons to the ETC where ATP is formed via oxidative phosphorylation. Highlights of Metabolism
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2. NADPH is the major electron donor in reductive biosynthesis 3. Central metabolic pathways have both anabolic and catabolic roles. formed primarily via the pentose phosphate pathway TCA is an excellent example.
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4. Distinct pathways for biosynthesis and degradation ensures favorable thermodynamics for both directions separate, but interrelated, control mechanisms (often the 1 st step) compartmentalization (e.g., cytosol vs. mitochondrial matrix)
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5. Many coenzymes coenzyme role example Niacin/B3 (NAD + ) redox malate dehydrogenase Riboflavin/B2 (FAD) redox succinate dehydrogenase Pantothenic acid/B5 acyl transfer pyruvate dehydrogenase Pyridoxal phosphate/B6 transamination α -KG --> Glu Vitamin B12 rearrangements propionyl CoA -> succinyl-CoA Thiamine/B1 (TPP) decarboxylation pyruvate dehydrogenase Biotin/B7 CO 2 carrier pyruvate carboxylase Lipoic acid acyl carrier pyruvate dehydrogenase Folic Acid/B9 carbon carrier amino acid degradation
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Which of the following coenzymes often participates in carboxylation reactions? A. Vitamin B12 B. TPP C. Flavin coenzyme D. Coenzyme A E. Biotin Coenzymes
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glucose-6-phosphate pyruvate acetyl-CoA glycogen pyruvate ribose-5-P acetyl-CoA lactate alanine OA CO 2 fatty acids ketone bodies 6. Several molecules act as metabolic junction points.
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7. A defect in a single enzyme of
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