Exam2 - BC 368 - Biochemistry of the Cell II 2004 Second...

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BC 368 - Biochemistry of the Cell II – 2004 Second Exam - ANSWERS MULTIPLE CHOICE: 1. d 2. b 3. b 4. d 5. c 6. a 7. d 8. a 9. a 10. b 11. This is a regulation question. Because fructose enters glycolysis where it does, the key control reaction for glycolysis is avoided. This could be a problem for many reasons. In addition, recall that fructose 1,6-bisphosphate allosterically activates pyruvate kinase at the end of glycolysis. In this example, fructose 1,6-bisphosphate is not generated so pyruvate kinase is also not regulated maximally. (Interestingly, there is not a big savings of energy in the fructose pathway either…the enerby is saved only by not substrate cycling like in Rxn 3 of glycolysis) 12. Inhibiting the malate-aspartate shuttle will prevent the passage of reducing equivalents from the cytosol to the mitochondria. A) Glycolysis rate increases. As NADH levels build, the cell switches to fermentation to supply ATP to meet its energy demands. Because less ATP is made through anaerobic means than through aerobic means, the glycolytic pathway speeds up. B) Oxygen consumption decreases a lot. Because pyruvate is converted to lactate, it doesn’t enter the mitochondria. Without new acetyl-CoA, the TCA will stop, and electrons will not enter the ETC. The result is that no O2 is used. C)
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This note was uploaded on 10/12/2010 for the course BC BC367 taught by Professor Millard during the Spring '10 term at Colby.

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Exam2 - BC 368 - Biochemistry of the Cell II 2004 Second...

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