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glycolysis - 3 Phosphorylation C Hexokinase vs glucokinase...

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BC368 – Biochemistry of the Cell II Carbohydrate Catabolism Topics: Readings in Lehninger I. Central Role of Glucose pp. 527-528 II. Glycolysis Pathway pp. 528-541 A. Purposes B. Types of transformations C. Reactions of Phase I (Preparatory phase) 1. Why phosphorylations at step 1? 2. Enzymes and irreversible reactions 3. “TIM” D. Reactions of Phase II (Payoff phase) 1. Covalent catalysis 2. Substrate-level phosphorylations 3. Role of BPG E. Efficiency F. General trends III. Fermentations pp. 542-546 A. Lactic acid B. Ethanol 1. Pyruvate decarboxylase and TPP 2. Alcohol dehydrogenase IV. Entry of Other Hexoses and Glycerol pp. 549-551 V. Glycogen Breakdown pp. 547-548 A. Glycogen phosphorylase B. Debranching enzyme VI. Glycolysis Regulation pp. 551-557 A. PFK-1 1. Allosteric inhibitors 2. Allosteric activators B. Pyruvate kinase 1. Allosteric inhibitors
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Unformatted text preview: 3. Phosphorylation C. Hexokinase vs. glucokinase VII. Regulation of Glycogen Metabolism pp. 557 VIII. Pentose Phosphate Pathway pp. 558-560 A. Makes NADPH and D-ribose-5-P B. Pathway ____________________________________ Some things to consider while you’re reading: • Glycolysis is probably the closest we will get to a truly universal pathway. It is the central metabolic pathway in a wide variety of organisms. • Begin to consider what will happen to an individual if they are deficient in one of the enzymes in the metabolic pathways we discuss. Consider the effect on the intermediates in the pathway, on the pathway as a whole, and on the organism as a whole. Is it always a straightforward relationship?...
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