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Solutions1 - BC368 Biochemistry of the Cell II Problem Set...

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BC368 – Biochemistry of the Cell II Problem Set #1 – Membrane Structure ANSWERS 1. The fatty acyl chain in sphingomyelin is linked in an amide linkage, so SP is not a substrate for phospholipase A 2 . In addition, only lipids in the exoplasmic monolayer of the membrane are accessible to the enzyme. The % of each class hydrolyzed by phospholipase A 2 represents the amount of that phospholipid in the outer monolayer (except for SP). The %age of the total phospholipd in each class found in the outer monolayer can be determined by multiplying the values in the two columns of the table together: 40% total X 70% outer = 28% PC, 30% total X 30% outer = 9% PE, 5% total X 10% outer = 0.5% PI, and 10% total X 5% outer = 0.5% PS = 38%. Since the outer monolayer contains 50% of all the phospholipids, then SP in the outer monolayer must be 12% (50% - 38%) of the total phospholipid. The composition of the outer leaflet can be calculated by dividing the percentage of the total phospholipids in the outer leaflet by 1/2, giving 56% PC, 18% PE, 24%
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Solutions1 - BC368 Biochemistry of the Cell II Problem Set...

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