BB lecture 10-2 endomembrane sys

BB lecture 10-2 endomembrane sys - Chapter 6: Cell...

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Chapter 6: Cell structure (continued, pp.103-111) - Endomembrane system: RER, SER, vesicles, Golgi, vacuoles & lysosomes… Learning objectives Be able to draw the structure of the nucleus nucleus , and discuss a possible explanation for its double membrane . • Describe the major structures and functions of the endomembrane system (EMS), and understand that the inner spaces of the system are continuous with the nuclear membrane, and separate from the cytoplasm • Compare the structure and functions of smooth and rough ER • Be able to explain the relationship of Golgi, lysosomes, and vacuoles as part of the EMS, and their functions • Explain the basis of the lysosomal disorder known as Tay Sachs disease • Describe the evidence that mitochondria and chloroplasts are semiautonomous organelles
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ENDOSYMBIOSIS (mitochondria, plastids) CELL MEMBRANE INFOLDING (endoplasmic reticulum, nuclear membrane)
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‘Ancestral prokaryote’ invagination and infoldings of plasma membrane of eukaryotes ?
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Endomembrane System Structurally … The endomembrane system includes… the nuclear membrane endoplasmic reticulum Golgi structures lysosomes vacuoles Functionally… The endomembrane system regulates protein traffic and performs diverse metabolic processes
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The big picture… NOT PART OF THE EMS !
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In many eukaryotic cells, the endoplasmic reticulum ( ER ) makes up about half of the membranes in the cell. Structurally… -it is continuous with the nuclear envelope. . called “cisternae” having an interior – the “lumen”. . -there are distinct regions due to ribosomal presence/absence > Regions appear ‘rough’ or ‘smooth’
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Structure: Rough ER… endomembrane structure with attached ribosomes… [micrographs appear “rough”] Functions: RER Produces secretory proteins (most are glyco proteins) Secretory proteins are not “free” in the cytosol These are transported throughout cell by vesicles (membranous containers) Produces membrane proteins and phospholipids as ER grows
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As  they  enter  into  the  ER  lumen,  some polypeptides become ‘trapped’ in the lipid bilayer,  where  they  remain.  They  are called  transmembrane proteins .
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Structure: Smooth ER… endomembrane structure without attached ribosomes,… [ micrographs appear “smooth”] Functions: SER… Synthesizes lipids (oils, phospholipids, steroid hormones Metabolizes carbohydrates Stores calcium Detoxifies drugs, poisons
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Structure Consists of flattened membranous sacs called cisternae Functions Receives transport vesicles coming from RER
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BB lecture 10-2 endomembrane sys - Chapter 6: Cell...

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