BB lecture 11-5 DNA history & structure

BB lecture 11-5 DNA history & structure - Chapter...

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Chapter 16 (pp.293-298) DNA – Structure and function (history) Learning objectives Explain why researchers originally thought protein was the genetic material. Know the early experiments that contributed to the discovery of DNA structure Griffith Avery Hershey and Chase Know the contributions of: Chargaff Describe the structure of DNA. Explain the base-pairing rule and describe its significance. Remember that nucleic acid strands are anti-parallel and have distinct 5’ and 3’ polarity
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1869… Friedrich Miescher discovers "nuclein" in the cells from pus in open wounds -- cells composed mostly of nuclear material. 1874… Miescher separated it into a protein and an acid molecule - nuclein then became known as nucleic acid . Function unknown; hereditary process suspected. 1920s. . Nucleic acid found to be a major component of chromosomes 1930s. . Chemical nature of nuclei acid was thought to be a tetranucleotide composed of one unit each of adenylic, guanylic, thymidylic and cytidylic acids DNA – What did we know and when did we know it?
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DNA – the early years… The question: What carries genetic information? The suspects: Protein (the favorite, because complex) DNA (maybe, but too simple) The main characters, (in order of appearance): - Frederick Griffith (1928) - Oswald Avery (1944) - Alfred Hershey and Martha Chase (1952)
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Oswald Avery Alfred Hershey and Martha Chase Frederick Griffith (w/ W. Hendricks)
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Figure 16.2 Can the genetic trait of pathogenicity be transferred between bacteria?
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BB lecture 11-5 DNA history & structure - Chapter...

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