BB lecture 11-16 mutations

BB lecture 11-16 mutations - For clarification What is a...

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For clarification… What is a transcription unit ? A transcription unit is the DNA sequence that is transcribed into RNA (e.g., m RNA, t RNA,et.seq. …) What is a gene ? A gene is a region of DNA whose final product is either a polypeptide or an RNA molecule – includes non-transcribed sequence (e.g., promoter, terminator…)
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Chapter 17 (pp. 327-331) – Mutations Learning objectives Define mutation ; define point mutation Give an example of how a point mutation can be harmless; or harmful. Explain the basis for sickle cell anemia Understand the significance of a frameshift mutation Define mutagen ; describe examples of mutagens Be able to distinguish between a gene and a DNA transcription unit
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Mutation-- a change in a gene’s DNA . Mutations that cause cancer are typically called “carcinogens” A spontaneous mutation is one that occurs as a result of natural processes in cells (during replication, recombination, or repair). Point mutations: changes in a single base pair of a gene may change an amino acid codon to a termination codon or vice versa. .can result in a prematurely shortened protein may be silent , NOT resulting in a new amino acid in the protein sequence – often true in the third position of a codon, because of "wobble" base pairing
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Types of Point Mutations Point mutations - two general categories 1. Base-pair substitutions 2. Base-pair insertions or deletions
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Substitutions A base-pair substitution replaces one nucleotide and its partner with another pair of nucleotides Base-pair substitution can cause missense
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This note was uploaded on 10/06/2010 for the course BIO 311C taught by Professor Satasivian during the Fall '08 term at University of Texas at Austin.

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BB lecture 11-16 mutations - For clarification What is a...

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