Environmental Carcinogenesis - ENVIRONMENTAL CARCINOGENESIS...

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ENVIRONMENTAL CARCINOGENESIS Dr. V. JAGADEESAN Former Deputy Director (Senior Grade) FOOD AND DRUG TOXICOLOGY RESEARCH CENTRE NATIONAL INSTITUTE OF NUTRITION Indian Council of Medical Research Hyderabad - 500 007
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Cancer is one of the leading causes of death around the world. In India, the annual estimate of cancer for the year 2001 is 0.98 million and the annual mortality in 2000 was 0.7 million. Till recently there were no proper records of cancer incidence in our country, but ever since the establishment of Cancer Registries in different Centres by the Indian Council of Medical Research, it has been possible to assess it, which suggests that more and more cases of cancer's are surfacing. The cancer incidence is thus on the increase. The picture in USA is even more grim. A third of all Americans will get cancer, with about 1.2 million new cases and around 550000 deaths in the year 2000 according to American Cancer Society. ENVIRONMENTAL CARCINOGENESIS
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Carcinogens can cause tumour formation by at least three ways: as mutagens (or genotoxins), as co-carcinogens and as tumour promoters. Genotoxins are compounds which directly attack the DNA to cause altertations in them, a process called mutagenesis. The structural abnormality thus caused, will lead to formation of new cells, which no longer represent the original parental DNA and thus results in a new cell formation i.e. neoplasia or cancer.
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i. Activation and Binding ii. DNA Repair iii. Apoptosis
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The earliest confirmation of the notion that environmental factors may play a role in the occurrence of cancer was reacted when John Hill noted the development of nasal cancer as a consequence of excessive use of tobacco snuff; he was followed in 1775 by Percival Pott, who noted the unusually high incidence of scrotal cancers in workers, who used to clean and scrub the carbon soots in the chimneys in England.
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The experimental investigation
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This note was uploaded on 10/07/2010 for the course DBT 456 taught by Professor Ss during the Spring '10 term at Indian Institute of Technology, Guwahati.

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Environmental Carcinogenesis - ENVIRONMENTAL CARCINOGENESIS...

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