Hepato Toxicity - HepatoToxicity DR.V.JAGADEESAN...

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    Hepato Toxicity   DR. V. JAGADEESAN Former Deputy Director ( Sr. Gr. ) National Institute of Nutrition Hyderabad Lecture at  HCU 1. Concepts in Toxicology 2. 3. Stine, K et al – Principles of Toxicology
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    Introduction Principal Organ - Largest Gland in  the body Five Lobes - Each lobe consists of many small lobes, made up of liver  cells or HEPATOCYTES  Lobules are arranged in distinct hexagonal pattern within a lobe  Columns of epithelial cells called Hepatocytes appear to radiate from a  central vein, which is actually a branch of the hepatic vein These columns of hepatocytes have between them channels called  SINUSOIDS , which are lined with highly permeable endothelial cells   containing  phagocytic cells called  KUPPFER cells  BILE which is produced in the hepatocytes flow out through BILE  CANALICULI (located between adjacent hepatocytes) to the bile ducts  
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    Liver Structure I
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    Liver Structure II
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    Liver Functions Bile secretion  Detoxification Regulation of blood sugar Deamination of amino acids. Utilisation of stored fat  Storage of iron Storage of B 12 Formation of Fibrinogen Formation of non protein nitrogen
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    Carbohydrate Metabolism When blood glucose levels increase  (following a meal), hepatocytes are capable  of converting sugars, fats and amino acids  into glucose and then storing glucose (in the  form of polysaccharide - GLYCOGEN) 
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This note was uploaded on 10/07/2010 for the course DBT 456 taught by Professor Ss during the Spring '10 term at Indian Institute of Technology, Guwahati.

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Hepato Toxicity - HepatoToxicity DR.V.JAGADEESAN...

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