Models to Study Drug Metabolism

Models to Study Drug Metabolism - ModelstoStudyDrug...

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    1 Models to Study Drug  Metabolism Dr. V. Jagadeesan,  Former Deputy Director (Sr. Grade),  National Institute of Nutrition, Hyderabad 1. Concepts in Toxicology – DRDO 2. Safety Assessments for Pharmaceuticals - Shane C Gad
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    2 Models to Study Drug Metabolism 4 – 5 million compounds in environment  Upto 1000 chemicals enter  commerce every year In order to evaluate the activity and metabolism of new  compounds, various invitro systems are initially adopted  Biological Models are selected on the basis of the  pharmacological / toxicological question Cells of hepatic origin are more relevant to studies of  hepatotoxicity than neurotoxicity and vice versa
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    3 Potential Biological Components for In Vitro  Testing systems Organ Culture Tissue Culture  Primary Cells  Suspension Culture Plated Culture  Sub cellular Organelles  Cell lines 
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    4 Isolated Organ perfusion Techniques  Heart Lung Liver  Kidneys  Brain Intestines Pancreas 
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    5 Possible Cellular Functions that can be  exploited to evaluate intrinsic cellular toxicity 1. Maintenance of gross integrity of cellular membranes . 2. Regulation of physiologically important ions ( e.g. K+,  Na+,Ca++ ) 3. Regulation of bio-chemically important substrates ( e.g.  amino acids, sugars, glutathione) 
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This note was uploaded on 10/07/2010 for the course DBT 456 taught by Professor Ss during the Spring '10 term at Indian Institute of Technology, Guwahati.

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Models to Study Drug Metabolism - ModelstoStudyDrug...

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