PrinTox & DetoxMech - Combi

PrinTox & DetoxMech - Combi - PRINCIPLES OF TOXICOLOGY...

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Unformatted text preview: PRINCIPLES OF TOXICOLOGY & DETOXIFICATION MECHANISMS Dr. V. JAGADEESAN Former Deputy Director (Sr. Gr.) FOOD AND DRUG TOXICOLOGY RESEARCH CENTRE NATIONAL INSTITUTE OF NUTRITION Indian Council of Medical Research HYDERABAD – 500 007 PRINCIPLES OF TOXICILOGY PRINCIPLES OF TOXICOLOGY General Introduction Study of adverse effects of chemicals or other agents on living systems in order to predict hazard to man and his environment Based on principles of pharmacology Toxicology Long term Short term (Chronic) (Acute) Slow piling up of a foreign agent over Ingestion of poisonous a course of time or sustained exposure substances to sublethal amounts of substance MULTIDISCIPLINARY SPEATIONS OF TOXICOLOGY a. Type of Activity Biochemical Toxicol. -Metab. of Xeno. Analytical Toxicol. -ELISA for adducts of BP Clinical Toxicol. -Drug Meta. Environ. Toxicol. -Pollut. Economic Toxicol. -Impact of Eco. Forensic Toxicol. -Medico legal poisons) Industrial Toxicol. -Benzidine dye/MIC Regulatory Toxicol. -Safe limits establish b. Class of Animals/Plants/Insects Insect Toxicology -e.g. Rice Moth Larvae Veterinary Toxicology -Animals, Equine (Farm Animals) Human Toxicology Phyto Toxicology -Pea Barley Rye (Germ.is affected Eco Toxicology c. Mammalian System Immuno Toxicology Molecular or Cell Toxicology Hepato Toxicity -CCl 4 , AFB Renal Toxicity -Pb Neuro Toxicity -Lathyrus Behavioral Toxicity -Vicia Faba Pulmonary Toxicity Embryo Toxicity Fetal Toxicity d. Route of Exposure Inhalation/Dermal/Systemic e. Class of Agents e.g. Fish; Snake toxins f. Class of Chemicals Pesticide Toxicity Metal Toxicity, Drug Toxicity, Food Toxicology, FACTORS AFFECTING TOXICITY OF COMPOUNDS Nature of compound a. Size of the particle : (Smaller the greater solubili) b. Solubility c. Polarity Solubility Smaller the particle, greater the solubility. More easily absorbed through the gut. Inhalation of particles of varying sizes causes respiratory distress and allergy. While non-absorbable or insoluble substances may be thought to be non-toxic, there are certain exceptions like asbestos and coal dust. TERMINOLOGIES IN TOXICOLOGY 1. Local vs Systemic Toxicity Salicylates -Irritation in Gl mucosa ; local Toxi....
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This note was uploaded on 10/07/2010 for the course DBT 456 taught by Professor Ss during the Spring '10 term at Indian Institute of Technology, Guwahati.

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PrinTox & DetoxMech - Combi - PRINCIPLES OF TOXICOLOGY...

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