REPRODUCTIVE TOXICOLOGY - REPRODUCTIVE AND DEVELOPMENTAL...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
1 REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY Dr. V.JAGADEESAN 1. Comprehensive Toxicology Vol. 2 2. Steine K. E. et al Principles of Toxicology 3. Concepts in Toxicology
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 REPRODUCTIVE TOXICOLOGY Defined as that part of general Toxicology dealing with adverse effects of xenobiotics on the reproductive processes. TERATOGENICITY Represents a specific module within this framework and relates ONLY to the effects of test chemicals on embryonic / fetal growth and their ability to induce MALFORMATIONS recognisable at birth or at later stages. In humans, the presence of abnormalities leads to spontaneous abortion of somewhere between 25-50% of all pregnancies. 10-15% of all live births show birth defects Reasons Random genetic errors + Environmental Factors
Background image of page 2
3 MALE REPRODUCTIVE ORGAN TESTES Vascular Interstitial Tissue containing Leydig’s cells Seminiferous tubules containing Sertoli & Germ cells (sperms are produced here) Sperms from Seminiferous tubules are initially deposited in Epididymis then move along after maturation and motility along Vas deferens to the ejaculatory duct.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 FEMALE REPRODUCTIVE ORGAN Ovaries on either side contain all oocytes Oocytes along with cells that surround them are called primary follicles These increase in number during ovulation, though only one oocyte is released Oocytes contained in the follicle travel down to the fallopian tubes , to get fertilized and travel down to the Uterus for development. The follicles becomes Corpus Luteum supported the zygote in earlier days ( fertilized ovum ) or degenerate and thrown off during menstruation
Background image of page 4
5 TOXICANTS AND THEIR EFFECTS ON MALE AND FEMALE REPRODUCTIVE ORGANS Compounds Site Effect / Mechanism Alkylating Agents Anti metabolites X- Rays Ionising radiations PCBs DDT M+F Spermatogenesis / Oogenesis Interfere with cell division Decreases and inhibits nucleotide biosynthesis Damages DNA Effects on dividing cells. Adverse effects on human reproductive health.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 TOXICANTS AND THEIR EFFECTS ON MALES Compounds Site Effect / Mechanism Dibromo chloro propane (DBCP) DNB DN toluene Phthalates (Plasticizing Compounds) Lead Cadmium Ethanol Pesticides CS2/ DDT/ tobacco Anabolic steroids Seminiferous tubule Epithelium Testes Destruction Effect on energy metabolism Testicular necrosis Chromosomal damage Delayed development Abnormal sperms
Background image of page 6
7 TOXICANTS AND THEIR EFFECTS ON FEMALES AGENT SITE EFFECT / MECHANISM Anti neoplastic agent Primary oocytes Damage oocytes a) Temporary infertility, if mature secondary oocytes are affected ;if primary oocytes are involved , temporary infertility +early onset of menopause b) DNA damage leading to genetic defects in offsprings. c)
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/07/2010 for the course DBT 456 taught by Professor Ss during the Spring '10 term at Indian Institute of Technology, Guwahati.

Page1 / 36

REPRODUCTIVE TOXICOLOGY - REPRODUCTIVE AND DEVELOPMENTAL...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online