Plasma cell disorder - Plasma cell disorders Plasma Cells...

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Plasma cell disorders
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Plasma Cells Disorders Objectives The learners should be able to 1. List laboratory tests for evaluation for plasma cell l disorders 2. State mechanism and pathophysiology of disease 3. List of classification of plasma cell disorders 4. Describe the significance of laboratory manifestation and investigation of plasma cell disorders
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Definition Plasma cell dyscrasia : A syndrome of abnormal proliferation of antibody producing cell (plasma cell) Paraproteinemia : Presence of abnormal protein (mostly monoclonal or M-protein) which are the secretory products of malignant plasma cells
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Serum electrophoresis
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Classification 1. Multiple myeloma 2. l Waldenstorm’s macroglobulinemia 3. Heavy chain disease 4. Cryoglobulinemia 5. Monoclonal gammopathy of undetermined significance (MGUS) 1. Amyloidosis 2. Plasma cell leukemia
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Immunoglobulin
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Multiple Myeloma Definition : Malignant proliferation of plasma cell Epidemiology : - 1% of malignancy, 10-15% of hematologic malignancy - M/F = 2/1, Black/White = 2/1 - Median age 70 yr - Risk factors : Radiation, Benzene, Dye, Chemicals Etiologic factors : - Genetics - Chronic antigenic stimulation
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Sign and Symptoms Sign Symptoms Anemia Tiredness Fatigue Shortness of breath Hypercalcemia Mental status change Bone pain Kidney stones Abdominal pain Renal failure None (until late) Bone lesion Bone pain Mass Fracture
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Sign and Symptoms Sign Symptoms Elevated serum globulin
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This note was uploaded on 10/07/2010 for the course DBT 446 taught by Professor Dd during the Spring '10 term at Indian Institute of Technology, Guwahati.

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Plasma cell disorder - Plasma cell disorders Plasma Cells...

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