311-361-15-1 - Immunologic Tolerance Self/nonself...

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Immunologic Tolerance Self/nonself discrimination Self-tolerance Failure of self-tolerance Autoimmune diseases
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Site Thymus Central Tolerance of T cells
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Peripheral T cell Tolerance Site Periphery stage Mature T lymphocyte Stimuli Ag presentation by APCs lacking costimulators; repeated stimulation by self Ag Mechanisms anergy activation-induced cell death suppression of T cells
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Autoimmunity Autoimmunity: any disease in which immune reactions accompany tissue inj ury Etiology: ??
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General Concepts of Autoimmunity -Autoimmunity results from a failure or breakdown of the mechanisms responsible for maintaining self-tolerance - Multiple interacting factors contribute to the development of autoimmunity -Autoimmune diseases may be either systemic or organ specific - Various effector mechanisms are responsible for tissue injury in different autoimmune diseases
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-Autoimmunity may result from primary abnormality of B cells, T cells or both. -failure of T cell tolerance
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This note was uploaded on 10/07/2010 for the course DBT 446 taught by Professor Dd during the Spring '10 term at Indian Institute of Technology, Guwahati.

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311-361-15-1 - Immunologic Tolerance Self/nonself...

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