MCDB 1A - 1>EN1Genetics>ENWhat is Genetics?•Study...

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Unformatted text preview: 1->EN1Genetics->ENWhat is Genetics?•Study of Genes–Transmission Genetics(inheritance of traits)–Molecular Genetics (DNA > RNA > polypeptide)–Population Genetics(genetic variation in groups of individuals)•Study of whole genomes = genomics2->ENHow to study genetics•Read the textbook•Attend lecture and take notes!•"Some Genetics Problems" in text (pages 230-231)–PDF answer key•Four online genetic quizzes–Each quiz is worth 1 extra credit point if you score 90% or more.•Review last year's final exam•Get help from me, TA, or CLAS3->ENMCDB 1A Genetics Syllabus•Genetics: Mendel and Beyond Chpt10 –Mendel’s Experiments and the Laws of Inheritance –Alleles and Their Interactions –Gene Interactions –Genes and Chromosomes –Sex Determination and Sex-Linked Inheritance •Genetics of Viruses and Prokaryotes Chpt13 –Virus life cycles(pg 283-289) –Plasmids (pg 293-295) –Regulation of Gene Expression in Prokaryotes (pg 296-300) –ProkaroticGenomes (pg 300-303) •Eukaryotic Genome and Expression Chpt14 –The Eukaryotic Genome –Gene Regulation of Eukaryotic Genes –Chromatin Structure –Barr Bodies •Recombinant DNA and Biotechnology Chpt16 –Cleaving and Rejoining DNA –Cloning Genes –Biotechnology: Applications of DNA Manipulation •Molecular Biology and Medicine Chpt17 –Protein as Phenotype –Mutations and Human Diseases –Detecting Human Genetic Variations –Treating Genetic Diseases42->ENGenetic Vocabulary•allele•crossing over•dihybrid•diploid•dominant•gene•genotype•haploid•heterozygote•homologous chromosomes•homozygote•law of independent assortment•law of segregation•linked•locus•monohybrid•pedigree•phenotype•recessive•segregation•self-fertilization•sex linkage•testcross•X chromosome•Y chromosome•zygote5->ENGray Wolf~ 15,000 yearsDomestic DogWhere did dogscome from?6->ENEvolutionary Relationships of the Dog7from http://www.kc.net/~wolf2dog/wayne2.htmGenome Res. 2005 Dec;15(12):1706-16.->ENDog Genome Project8•Comparing 85 purebred dog breeds showed that each was genetically distinct.•Some breeds are more cluster more closely with the wolf genome•Each Dog breed has distinctive heritable traitsFrom: Genetic Structure of the Purebred Domestic Dog, Science 21May 2004: 1160-1164.3->ENA Single IGF1Allele Is a Major Determinant of Small Size in DogsThe extreme diversity in body size among purebred dogs is greater than that of any other mammalian speciesScience6 April 2007: Vol. 316. no. 5821, pp. 112 -115 ->ENDr. Christoffersen’sDog Charlie was a hybrid and inherited his coat traits from both parentsCharlie9CharlieGoldenretrieverBlack Lab->ENWhat other dog traits are heritable?•Coat color patterns•Bone structure•Body size•Tail Curl•Temperament = personality1010->ENAre human behavioral or personality traits heritable?•Twin studies show that many human traits have a strong genetic componentTraitMonozygotic(100 % shared genes)Dizygotic...
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This note was uploaded on 10/08/2010 for the course MCDB MCDB 1A taught by Professor Senghuilow during the Summer '09 term at UCSB.

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MCDB 1A - 1>EN1Genetics>ENWhat is Genetics?•Study...

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