MCDB 1A - What is Genetics Study of Genes Genetics...

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1 -> E N 1 1 Genetics -> E N What is Genetics? Study of Genes – Transmission Genetics (inheritance of traits) – Molecular Genetics (DNA > RNA > polypeptide) – Population Genetics (genetic variation in groups of individuals) Study of whole genomes = genomics 2 2 -> E N How to study genetics Read the textbook Attend lecture and take notes! "Some Genetics Problems" in text (pages 230- 231) PDF answer key Four online genetic quizzes Each quiz is worth 1 extra credit point if you score 90% or more. Review last year's final exam Get help from me, TA, or CLAS 3 3 -> E N MCDB 1A Genetics Syllabus Genetics: Mendel and Beyond Chpt 10 Mendel’s Experiments and the Laws of Inheritance Alleles and Their Interactions Gene Interactions Genes and Chromosomes Sex Determination and Sex-Linked Inheritance Genetics of Viruses and Prokaryotes Chpt 13 Virus life cycles (pg 283-289) Plasmids (pg 293-295) Regulation of Gene Expression in Prokaryotes (pg 296-300) Prokarotic Genomes (pg 300-303) Eukaryotic Genome and Expression Chpt 14 The Eukaryotic Genome Gene Regulation of Eukaryotic Genes Chromatin Structure Barr Bodies Recombinant DNA and Biotechnology Chpt 16 Cleaving and Rejoining DNA Cloning Genes Biotechnology: Applications of DNA Manipulation Molecular Biology and Medicine Chpt 17 Protein as Phenotype Mutations and Human Diseases Detecting Human Genetic Variations Treating Genetic Diseases 4 4
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2 -> E N Genetic Vocabulary allele crossing over dihybrid diploid dominant gene genotype haploid heterozygote homologous chromosomes homozygote law of independent assortment law of segregation linked locus monohybrid pedigree phenotype recessive segregation self-fertilization sex linkage testcross X chromosome Y chromosome zygote 5 5 -> E N Gray Wolf ~ 15,000 years Domestic Dog Where did dogs come from? 6 6 -> E N Evolutionary Relationships of the Dog 7 7 from http://www.kc.net/~wolf2dog/wayne2.htm Genome Res. 2005 Dec;15(12):1706-16. -> E N Dog Genome Project 8 8 •Comparing 85 purebred dog breeds showed that each was genetically distinct. •Some breeds are more cluster more closely with the wolf genome •Each Dog breed has distinctive heritable traits From: Genetic Structure of the Purebred Domestic Dog, Science 21 May 2004: 1160-1164.
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3 -> E N A Single IGF1 Allele Is a Major Determinant of Small Size in Dogs The extreme diversity in body size among purebred dogs is greater than that of any other mammalian species Science 6 April 2007: Vol. 316. no. 5821, pp. 112 - 115 -> E N Dr. Christoffersen’s Dog Charlie was a hybrid and inherited his coat traits from both parents Charlie 9 9 Charlie Golden retriever Black Lab -> E N What other dog traits are heritable?
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