Viruses - Viruses Virus Text: Genetic element with either...

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Viruses Virus Text: Genetic element with either DNA or RNA, but not both Obligate requirement to replicate inside a living cell Has an extracellular state (virion) Living organism or life-form?
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Mimivirus Contains DNA and RNA World’s largest virus
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Viruses Virology Reasons for study General biological interest Medical Economic Biotechnology
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Virus Properties States Extracellular State (virion) Metabolically inert Nucleic acid Protein capsid Envelope, if required Intracellular State Infection Takes over host’s cell metabolism Replication
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Virus Properties Genomes
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Virus Properties Structure Size Smaller than cells 0.2 – 0.3 µ Nanometers (1 nm = 1000 µ) Capsid Structural subunits (protein) Capsomere Nucleocapsid Enzymes Virus membrane (envelope) Self-assembly
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Virus Properties Structure Symmetry Arrangement of protein subunits Rod-shaped (helical symmetry) Spherical (icosahedral) Enveloped viruses Membrane acquired while exiting host cells Common in animal viruses Important in host cell penetration
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Naked & Enveloped Viruses
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Helical Symmetry
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Icosahedral Symmetry
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Enveloped Viruses
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Complex Viruses
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Virus Properties Enzymes Initiate early events of infectious process Viral-encoded Lysozyme Nucleic acid polymerases Reverse transcriptase Neuraminidase
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Cell Cultures Host cells Bacteriophage (host: bacterium)
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This note was uploaded on 10/09/2010 for the course MCB 3020C taught by Professor Safranek during the Summer '10 term at University of Central Florida.

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Viruses - Viruses Virus Text: Genetic element with either...

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