Medical Microbiology - Medical Microbiology Human-Microbe...

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Medical Microbiology Human-Microbe Interactions Parasites Pathogens Virulence Host resistance Infection Disease Normal flora
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Normal Flora
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Normal Flora Skin Dry, acidic environment Most organisms associated with apocrine (sweat) glands Transient vs resident flora Gram-positive organisms dominate
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Normal Flora Oral Cavity Complex environment Saliva Few nutrients Antibacterial components Lysozyme Lactoperoxidase Teeth Dental plaque Caries (cavities)
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Teeth
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Teeth
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Normal Flora Intestinal Tract
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Normal Flora Intestinal Tract Flora Vitamin B 12 , K production Steroid modification Metabolizing plant polysaccharides, amino acids Detoxifying dangerous foreign chemicals ~33% wt of feces Large intestine: chemostat Disruption of normal flora Intestinal gas (H 2 , CO 2 , CH 4 )
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Normal Flora Respiratory Tract Upper tract Mucous membranes Lower tract Ciliated epithelial cells Particles <10µ Resident lung flora
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Normal Flora Urogenital Tract Bladder (sterile) Urethra Opportunistic pathogens Vagina Pre-puberty: no glycogen, alkaline Adult: glycogen produced, acidic (lactobacilli) Post-menopause: no glycogen, alkaline
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Harmful Interactions Pathogenesis Adherence Colonization
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Harmful Interactions
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Entry into the Host Breaks in skin, mucous membranes (wounds, lesions) Specific adherence Glycocalyx (capsule, slime layer) Fimbrae Pili
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Adherence
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Invasion Penetration of epithelium
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This note was uploaded on 10/09/2010 for the course MCB 3020C taught by Professor Safranek during the Summer '10 term at University of Central Florida.

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Medical Microbiology - Medical Microbiology Human-Microbe...

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