BIO201 - Lecture 29

BIO201 - Lecture 29 - Lecture #29. Wed. 4-2-08...

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Lecture #29. Wed. 4-2-08
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Announcements I will not be able to hold my office hours today (4-2-08)
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Receptor-mediated Endocytosis 1. Ligands bind to receptors on the outside of the cell. A classic example is LDL (low density lipoproteins) binding to LDL receptors 2. Clathrin binds to the transmembrane receptors and endocytotic vesicles form 3. The clathrin coat is shed, the endosome is acidified, the ligand is dissociated from the receptor and the rest is sorted into different endosomes and other compartments 4. If the ligand is needed by the cell, it is transported to the cytoplasm 5. The receptor is recycled to the plasma membrane 6. If new receptors are needed, they are made in RER and trafficked through the endomembrane system 1. 2. 3. 4. 5. 6.
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1. Autophagy: Primarily for degredation of dead mitochondria Mitochondria + ER autophagosome autophagolysosome lysosome 2. Phagocytosis: Bringing in particles, such as bacteria, from the outside Phagosome phagolysosome
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This note was uploaded on 10/10/2010 for the course BIO 201 taught by Professor Janicke during the Spring '08 term at SUNY Buffalo.

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BIO201 - Lecture 29 - Lecture #29. Wed. 4-2-08...

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