Some%20hints%20for%20synthesis%20for%20the%20third%20test

Some%20hints%20for%20synthesis%20for%20the%20third%20test -...

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Strategies for synthesis Look in the product for the functional group: 1.  **decorated ketone or further transformed ketone O O O R OH N R O CO 2 Et R 1 R 1 R 1 R 1 R 1 O OEt O EtO NaOEt Claisen 1.NaOEt/EtOH 2.R 1 X "Decorated" KETONE How can you make an ester? (carboxylic acid, alcohol, cat.H+) 2. **decorated carboxylic acid or its derivatives (further transformed carboxylic acid)
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COOH COOH COOEt COOEt R 1 R 2 COOEt COOEt R 1 R 2 COOH R 1 R 2 COOR R 1 R 2 CH 2 OH R 1 R 2 CONHR R 1 R 2 O R "decorated" ACID 3. **Look for double bond 
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Unformatted text preview: α,β-to the carbonyl. If it was in the starting material and not in the product it could be Michael addition O R Y Y - Michael donor O R double bond disappeared 4.** Look for the α,β-unsaturated ketone in the product (result of aldol). Other hints (self condensation – double the number of carbon atoms in the product) O O functional group transformation OH N H H H N O O...
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Some%20hints%20for%20synthesis%20for%20the%20third%20test -...

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