lecture_11_23

lecture_11_23 - Aplysia Gill Withdrawal Reflex Aplysia will...

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Aplysia Gill Withdrawal Reflex Aplysia will withdraw its gill. in response to ) touch on the mantle or siphon or 1) 2) Habituation: After repeated touches, Aplysia “learns” l ithd ill a strong or noxious stimulus to the head or tail, a touch on the mantle or siphon, or to no longer withdraw gill. Habituation: After repeated touches to the siphon or mantle, Aplysia “learns” to no longer withdraw gill to siphon or mantle touch. Cellular mechanism of habituation: After repeated firing of action potentials in sensory neuron, Ca++ channels in the terminal deactivate. What is the effect of this deactivation? Less calcium enters terminal, less transmitter is released. Less transmitter is released. Additionally, vesicles are depleted from the terminal. What is the effect of this depletion? Voltage-gated Ca 2+ channels deactivate after neuron fires repeated action potentials
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Sensitization or dishabituation: A noxious stimulus to the head or tail will increase the strength of the gill withdrawal reflex in response to siphon or mantle stimulation. Cellular mechanisms of sensitization and dishabituation: 10 Steps ) Serotonin released by facil interneuron onto terminal of siphon sensory neuron (1) Serotonin released by facil interneuron onto terminal of siphon sensory neuron (4) this increases cAMP (2) (3) Metabo receptor activates G-protein G-protein activates adenly cyclase ) P in sensory neuron terminal is positive longer. (5) (6) (7) < potassium leaves during AP this activates PKA which phosphorylates VG-K channels, closing them (8) AP in sensory neuron terminal is positive longer.
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lecture_11_23 - Aplysia Gill Withdrawal Reflex Aplysia will...

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