sample_exam_2003

sample_exam_2003 - Print Name _ _ Exam 3, Fall 2003 pg. 1...

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Print Name __________________ ____ pg. 1 of 12 NEUROBIOLOGY 100 Exam 3, Fall 2003 I agree to have my exam returned to the boxes in Briggs Hall YES ___, NO ___ with the understanding that, if I checked no, the exam will only be available for pickup during office hours, and that if I check yes, sometimes exams out in the boxes mysteriously disappear Sign below to have your exams returned to the boxes. ___________________________________ TIME AND DATE OF THE SECTION YOU ARE ENROLLED IN ________ The name of your TA __________________________________________ points points 1 1 ______________ 0.7 6 1 ______________ 0.3 1 2 ______________ 1.3 6 2 ______________ 0.4 2 1 ______________ 0.7 6 3 ______________ 0.4 2 2 ______________ 0.6 6 4 ______________ 0.3 2 3 ______________ 1.1 6 5 ______________ 0.4 2 4 ______________ 0.4 7 ______________ 1.0 3 ______________ 0.8 4 1 ______________ 0.3 8 1 ______________ 0.3 4 2 ______________ 0.3 8 2 ______________ 0.3 4 3 ______________ 0.3 8 3 ______________ 0.3 4 4 ______________ 0.3 8 4 ______________ 0.3 4 5 ______________ 0.3 4 6 ______________ 0.3 B 1 ______________ 0.2 B 2 ______________ 0.4 5 1 ______________ 0.3 B 3 ______________ 0.2 5 2 ______________ 0.2 B 4 ______________ 0.4 5 3 ______________ 0.8 B 5 ______________ 0.2 5 4 ______________ 0.4 5 5 ______________ 0.3 5 6 ______________ 0.3 TOTAL (without bonus) 14 points 5 7 ______________ 0.3 bonud 1.6 points
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Print Name __________________ ____ pg. 2 of 12 Intensity (dB) Part 1. (Total 2 points) Refer to neurons 1 and 3, whose tuning curves are shown below Neuron 4 receives input from neurons 1 and 3. The synapse from neuron one to 4 ( neuron 1 Æ neuron 4 synapse ) is mediated by neurotransmitter receptors on neuron 4 that, when neurotransmitter binds to them, open sodium channels . The neuron 3 Æ neuron 4 synapse is mediated by neurotransmitter receptors on neuron 4 that, when neurotransmitter binds to them, open sodium and chloride channels with relative permeabilties of 0.4 for sodium and 0.6 for chloride . Given the following permeability and concentrations for the fluids around the synapses onto cell 4. [K + ] out = 15 mM [Na + ] out = 600 [Cl - ] out = 625 [K + ] in = 650 mM [Na + ] in = 100 [Cl - ] in = 100 At rest Pk = 1 At rest Pna = .11 At rest Pcl = .12 AP threshold = -22 mV ? Legend Denotes synapses that we do not tell you whether they are excitatory or inhibitory Neuron 3 ? ? Neuron 1 Neuron 4 5 10 15 20 0 20 40 60 80 Neuron 1 : CF = 5 kHz 5 10 15 20 0 20 40 60 80 Neuron 3 : CF = 15 kHz Frequency (kHz) Frequency (kHz) We will not look in this box!!!
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Print Name __________________ ____ pg. 3 of 12 Intensity (dB) Note: space is provided below the multiple-choice question to explain and show your math. 1.1 (0.7 Points) Which of the following is the tuning curve of cell 4 (note dark shaded areas are inhibitory, and un-shaded outlined areas are excitatory). There are areas that appear both excitatory and inhibitory (in C and F); this is OK because more information would be needed to determine which input was stronger in these potentially overlapping areas. 1.2 (1.3 Points) Explain your answer (show math below): __________________________________ _____________________________________________________________ _____________________________________________________________ _____________________________________________________________ Show math C 5 10 15 20 0 20 40 60 80 A. 5 10 15 20 0 20 40 60 80 Frequency (kHz) Frequency (kHz) 5 10 15 20 0 20 40 60 80 Frequency (kHz) 5 10 15 20 Frequency (kHz) 0 20 40 60 80 B 5 10 15 20 0 20 40 60 80 Frequency (kHz) 5 10 15 20 0 20 40 60 80 Frequency (kHz) D E F
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Print Name __________________ ____ pg. 4 of 12 Part 2 ( Total 2.8 points ). Below are the tuning curves of 3 primary auditory cortical neurons. All the tuning curves have identical shape and thresholds; they are just shifted in characteristic frequency (CF, also called best excitatory frequency in the book). Also the tuning curves do not go below 0 Hz, since there are no negative frequencies. While example tuning curves are shown for only three neurons (for a 5, 10 and 15 kHz neuron); there are neurons with CFs at all frequencies. For neurons with CFs at other frequencies, the tuning curves are identical in shape and simply shifted right or left to align the tip at the proper CF. Use this
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sample_exam_2003 - Print Name _ _ Exam 3, Fall 2003 pg. 1...

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