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Unformatted text preview: s one suggestion: try the reaction without the carbonyl group in the five-membered ring. The Fun in Base mechanism must fail, whereas the Cope could still work. It is not a perfect answer, though - why not? - we have made one of the competitors impossible - under such circumstances, the second best process could take over. Far better would be to do the reaction with optically active starting material. The Cope mechanism must produce optically active product whereas the aldol mechanism cannot. Easy if you see it. Remember that if you run a reaction in D 2 O/DO , all alpha and other acidic positions will exchange. You can t just hope that the one you want will exchange and the others not. Similarly, any deuterium in an alpha or other acidic position will wash out in H 2 O/HO ....
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