Skin - Skin(Integument Consists of three major regions 1 2...

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10/14/10 Skin (Integument) Consists of three major regions 1. Epidermis—superficial region 2. Dermis—middle region 3. Hypodermis (superficial fascia)— deepest region Subcutaneous layer deep to skin (not technically part of skin) Mostly adipose tissue
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10/14/10 Figure 5.1 Epidermis Hair shaft Dermi s Reticul ar layer Papilla ry layer Hypodermis (superficial fascia) Dermal papillae Po re Subpapillary vascular plexus Appendages of skin Eccrine sweat gland Arrector pili muscle Sebaceou s (oil) gland Hair follicle Hair root Nervous structures Sensory nerve fiber Pacinian corpuscle Hair follicle receptor (root hair plexus) Cutaneous vascular plexus Adipose tissue
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10/14/10 Epidermis Keratinized stratified squamous epithelium Cells of epidermis Keratinocytes—produce fibrous protein keratin Melanocytes 10–25% of cells in lower epidermis Produce pigment melanin
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10/14/10 Figure 5.2a Derm is Stratum corneum Most superficial layer; 20–30 layers of dead cells represented only by flat membranous sacs filled with keratin. Stratum granulosum 3 to 5 layers of flattened cells, organelles deteriorating; cytoplasm full of lamellated granules (release lipids) and keratohyaline granules. Stratum spinosum Several layers of keratinocytes unified by desmosomes. Cells contain thick bundles of intermediate filaments made of pre- keratin. Stratum basale Deepest epidermal layer; one row of actively mitotic stem cells; some newly formed cells ( a
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10/14/10 Layers of the Epidermis: Stratum Basale (Basal Layer) Stratum Deepest epidermal layer firmly attached to the dermis Single row of stem cells Journey from basal layer to surface Takes 25–45 days Cells contain a weblike system of intermediate prekeratin filaments attached to desmosomes Abundant melanin granules and dendritic cells
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10/14/10 Layers of the Epidermis: Stratum Granulosum Thin; three to five cell layers in which the cells flatten Lucidum (Clear Layer) In thick skin Thin, transparent band superficial to the stratum granulosum A few rows of flat, dead keratinocytes
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Skin - Skin(Integument Consists of three major regions 1 2...

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