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Document(3) - BIOLOGY 219 EXAM A October 2007 READ or LOSE...

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Unformatted text preview: BIOLOGY 219. EXAM A. October. 2007 READ or LOSE. Check to be sure there are at least 40 consecutively numbered questions- Each question is worth 2.5 points. Using a #2 pencil indicate the single best answer for each on your scantron. Print your name on the Scantron, and SIGN YOUR NAME beneath. NOTE: THIS IS TWO SEPARATE OPERATIONS!!! BUBBLE IN your 700-number on the Scantron. THE scantron MUST HAVE YOUR NAME PRINTED & SIGNED, and your full 700 number on it or your exam will not be graded. You must also indicate whether your exam form is form A or form B. l. The population of wild tigers has benefited from the development of: ’3‘ COX-2 inhibitors, e.g., celebrex Jar“ statins, e.g., Lipitor GD Viagra ,d: multiple vitamins fir pizza delivery in rural areas...(”do you want anchovies with that pizza delivery person or just peppers?”) 2. The transmembrane domain of a protein is expected to be composed principally of a. polar uncharged amino acid residues 13. polar positively charged amino acid residues c. polar negatively charged amino acid residues d. hydrophilic amino acid residues (e) hydrophobic amino acid residues \3": The expression of which cyclin(s) is/are controlled by extracellular mitogenic stimulation: J‘x __> x a. cyclinA __ b._ cyclin B A 'c, 'i'cycliu' 15,7 d. cyclifi'E 'jfik all are correct Cyclin BIA + Cdk1 Cyclin D's + Cdkn cdkfi Ip-u www-mu "flu-mph» Cyclin A + Cde Cyclin E 1- (did 4. On what part of the receptor protein—tyrosine kinase is the protein kinase activityhlocated? a. the extracellular surface ~15 the cytoplasmic region c. within the hydrophobic portion of the lipid bilayer f..- /‘ ‘ . . . ”/23. Cholera and pertussrs cause disease due to their effects on: f (a) G proteins _ ,bfPLC—gamma (phospholipase C—garnma) c. CAMP-directed PDEs (phosphodiesterases) / ,dr COMP—directed PDEs i e.” RTKs (receptor tyrosine kinases) My The effect of CDK—inhibitors (CDK-l) on the cell cycle is to: V7 48;) arrest the cell cycle, thereby preventing cell entry into S-phase " [hr arrest the cell cycle, thereby promoting cell entry into S—phase "r-—- N ,9: block pr and E2F interactions, thereby forcing cell entry into M-phase ' .dr phosphorylate p53, thereby terminating the cell cycle e. dephosphorylate the early cyclins, including cyclin D and cyclin E \ I The restriction checkpoint is part of which of the phases of the cell cycle: ' a. b. M .:—> _. -‘£' S d. G: e. G0 31-. The activation of protein kinase A results from: :3. an increased free intracellular calcium concentration ‘5 membrane depolarization /E. the binding of DAG (diacyl glycerol) 7 d. the binding of 1P3 by the regulatory subunits of PKA / PE) the binding of CAMP by the regulatory subunits of PKA 32. p53 is a transcription factor that is normally very short—lived in the cell (has a short half—life), but can be stabilized by: a. calmodulin binding b. proteolysis phosphorylation . dephosphorylation e. DAG (diacyl glycerol) 33. The products of PIP: (phosphatidyl—inositol-bis—phosphate) hydrolysis by PLC (phospholipase C) are: a. inositol and phosphatydic acid b. inositiol-bis—phoshate (1P2) and glycerol c. inositol—His phosphate (1P3) and glycerol—phosphate {a inositol—tris-phosphate (1P3) and diacylgiycerol (DAG) e. phosphatidyl-inositol-tris—phosphate (PIP3) 34. The increased activity of the nuclear protein Myc results in the loss of cell replication control. Thus. Myc is: a. a kinase b. a phosphoproteinphosphatase - . a tumor suppressor gene (7&3 an oncogene e. a cyclin 35. CDK4/6 is ineffective in the absence of: a. p53 b. ras c. the alpha subunit of G proteins (1. cyclin E @ cyclin D 36. By far, the most common type of kinase in cells are the: s'erine/threonine kinases b. serine/proline kinases c. serine/histidine kinases d. tyrosine kinases @ How is Ras activity turned off: a. It is turned off by phosphorylation. (7 ® 1: is turned off by hydrolysis of its bound GTP to GDP. ' 157 It is turned off by hydrolysis of its bound GDP to GTP. d. It is turned off by allosteric inhibition e. It is turned off by hydrolysis of its bound GTP to (3MP. 38. Some cancers exhibit a highly abnormal chromosome complement, wherein extra and/or missing chromosomes are evident, as is evidence of multiple translocations of the chromosomes. This condition is referred to as: a. karyotypic conundrums b. post—transformation nuclear disordering c. chromosomal deconstruction é) aneuploidy e. anharmonicisrn 39. The 1P3 receptor is found in the: C? endoplasmic reticulum . inner mitochondrial membrane c. ribosomes d. the nuclear envelope 40. Apoptosome assembly is triggered by the release of which of the following from the mitochondria: a. 1353 b. caspase—9 .12). cytochrome c d. glycogen e. citric acid ...
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