bicd2ans - 1 Construct the following pedigree and describe...

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1. Construct the following pedigree and describe what mode of inheritance that it most likely to represent: A proband affected male, marries a normal female. The father of the proband male was normal while the mother was affected. The proband couple has 5 children. The first two are identical twin unaffected girls. The next two children are affected boys. The final child is an affected girl. Assume the trait is rare and fully penetrant. (4pts) AUTOSOMAL DOMINANT (STUDY Q#1;PROB 6-17) 2. A family shows a strong history of individuals with long, thin fingers and toes and cardiovascular syndromes including several members who died from rupture of the aorta. Name the heredity disease associated with this system and choose (Circle) the one pedigree below that best matches this hereditary disease (3pts) MARFAN’S SYNDROME (STUDY Q#2,4,5) I II III IV 1 2 1 1 2 2 3 3 4 5 6 4 5 6 4 5 7 8 1 2 3
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I II III IV 1 2 1 1 2 2 3 3 1 2 3 4 5 6 4 5 7 I II III IV 1 2 1 1 2 2 3 3 1 2 3 4 5 6 4 5 7 8 3. Assume that the trait indicated in the following pedigree is rare, fully penetrant, and not sex-limited or sex- influenced. 7points (STUDY Q#2 and 3;prob 6-20,6-21 and others) a)What is the most likely mode of inheritance? List at least two reasons you chose this mode of ineritance. SEX-LINKED RECESSIVE 1.Affected females transmit disease to all sons (II-3;II-4) 2. Carrier female 1/2 chance to sons (III-3,IV-1) X B =normal X b =disease b)Assuming that this trait is controlled by two alleles, B and b. Define which is dominant and list the genotypes of the following individuals I-2___X b X b II-2__ X B X b _ II-3__ X b Y __ II-4__ X b Y III-3__ X b Y _ III-6 _ X B X b _ c) If III-6 and III-7 have another son, what is the probability that this son will be afflicted with the trait? If they have another daughter, what is the probability that she will be afflicted? Each son would have a 50% chance of inheriting the X b allele and have the disease Daughter’s would have a 0% chance of having the disease (50% chance of being a carrier) 4. . Assume that the trait indicated in the following pedigree is rare and fully penetrant. 7points a)What is the most likely mode of inheritance? List at least two reasons you chose this mode of ineritance. AUTOSOMAL DOMINANT;SEX-LIMITED OR SEX- INFLUENCED FEMALE 1. ONLY FEMALE AFFECTED 2. AFFECTED FEMALES GIVE DISEASE ONLY TO FEMALE (II-2 AND III-7 TO III-1 AND IV-3 3. CARRIER MALES (I-1 AND II-4) ONLY GIVE DISEASE TO FEMALE OFFPSRING (II-2 AND III- 7) SAYING AUTOSOMAL RECESSIVE WOULD MEAN THAT II-1 AND II-5 WOULD BOTH NEED TO BE CARRIERS…NOT LIKELY BECAUSE RARE DISEASE (STUDY Q#2,3;PROB 6-22,6-23) b)Assuming that this trait is controlled by two alleles, B and b, Define which is dominant and list the genotypes of the following individuals B=DOM I-1___Bb____I-2____bb_ II-2____Bb II-4___Bb III-1__Bb____ III-7 __Bb_ c) If III-7 and III-8 have another son, what is the probability that this son will be afflicted with the trait? If they have another daughter, what is the probability that she will be afflicted? 0% chance for male;50% female
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A. Cystic Fibrosis B.Sickle Cell anemia C. Tay-Sachs disease
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This note was uploaded on 10/14/2010 for the course BIOLOGY BICD 100 taught by Professor Stuart during the Spring '08 term at UCSD.

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bicd2ans - 1 Construct the following pedigree and describe...

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