2. Synaptic Transmission

2. Synaptic Transmission - Synaptic Transmission 1...

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Synaptic Transmission 1) electrical Synapses, direct electrical contact Gap junction pores between cells 2) chemical Synapses use neurotransmitter/receptors presynaptic neuron NTS receptor Synapse Post synaptic neuron I. Neuromuscular Junction (NMJ) a. Anatomy i. A alpha motor neuron 1. Vesicles in presynaptic terminal 2. Ca++ channel (P/Q type)- density/ active zones 3. Synaptic cleft 4. Muscle- post synaptic membrane a. Sub neural fold b. Receptors c. End plate where AP MAP ii. Vesicles 1. Lipid bilayer “bags” 2. Filled with Acetyle choline iii. Synaptic cleft 1. Filled with basal lamina- spongy with fluid- so it can diffuse through liquid raht than air iv. Receptors 1. Respond to Ach cholinergic 2. Sensitive to nicotine nicotinic 3. Abbreviation NmAChR a. Nicotinic muscle Acetyl Choline Receptor 4. Ligand-dependent ion channel/ non-specific cation a. When Ach is attached to receptor and opens up channel to allow the flow of cations b. NMJ function i. A alpha AP goes to presynaptic terminal
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This note was uploaded on 10/14/2010 for the course BIOLOGY bipn 100 taught by Professor Armour during the Spring '10 term at UCSD.

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2. Synaptic Transmission - Synaptic Transmission 1...

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