10. Electrophysiology of cardiovascular tissue

10. Electrophysiology of cardiovascular tissue - 10....

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10. Electrophysiology of Cardiovascular Tissue I. Cardiac muscle fibers a. Anatomy i. Small mononucleated ii. Electrically connected 1. “Intercalated disks” 2. Contract as a single unit b. Contractile Fibers i. Generate pressure ii. Striated Structure iii. Form atria/ventricles iv. “Myocardium” v. AP duration .2-.3 sec vi. Contraction duration .2-.3 sec 1. Cannot summate 2. Tetanus is bad need to relax to pump blood vii. Conduction velocity- .5 m/s 1. “Fast” phase a. 0- increase of P na+ fast depolarization b. 1- decrease of P na+, increase of Pk+ small repolarization c. 2- increase of P ca++= Ik+ Ca++ plateau d. 3- decrease of P ca++ (inactivation by Ca+ +:Calmodulin), increase of Pk+ repolarization e. 4- stable- Vrest c. Nodal fibers i. Sinoatrial Node ii. Atrial ventricular node iii. No striations- no contraction iv. Conduction velocity- .05m/sec 1. “slow phase” a. 0- increase of Pca++- slow depolarization b. 2- Ca++ plateau c.
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10. Electrophysiology of cardiovascular tissue - 10....

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