17. renal physiology

17. renal physiology - 17. Kidney- Renal physiology I....

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17. Kidney- Renal physiology I. Anatomy- two kidneys- 3 layers a. Renal cortex, renal medulla, renal pelvis ureter bladder- stores urine i. Renal artery/vein ii. Nephron- 2 mill b. Tubule system i. Bowman’s capsule glomerulus proximal tubule (cortex) (medulla) thin descending limb of loop of henle loop of Henle thin ascending limb of loop of Henle thick ascending limb of loop of Henle (medulla) (cortex) distal tubule collecting duct c. Blood supply i. Afferent arteriole Glomerulus in Bowman’s capsule efferent arteriole peritubular capillary along proximal/distal tubule Vasa recta (down loop of Henle) venule vein II. Urine- purpose of kidney a. Glomerulus i. Filtration- where blood filtrates ii. Bowman’s space- starling equation 1. Increase K, and Pc 2. Glucose, water, water solubles, small proteins, amino acids, urea 3. Small peptides cross ok 4. Large proteins- cross poorly 5. RBC- don't cross iii. Glomeluar filtration rate (GFR) 1. ~125 mL/min 2. fairly constant- even with change in BP 3. overall a. filtrate like plasma- isoosmotic to plasma b. few proteins iv. Reabsorption- filtrate to blood v. Secretion- blood to filtrate b. Proximal tubule i. Reabsorbs 1. 100% of glucose and proteins, amino acids- don't want to pee out 2. 70% of water and electrolytes
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This note was uploaded on 10/14/2010 for the course BIOLOGY bipn 100 taught by Professor Armour during the Spring '10 term at UCSD.

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17. renal physiology - 17. Kidney- Renal physiology I....

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