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DoseFormDesign-Part2-outline - University of Wyoming PHCY...

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University of Wyoming PHCY 6100 Teixeira 1 DOSAGE FORM DESIGN Part 2: Biopharmaceutical and pharmacokinetic considerations 1) Biopharmaceutics: relationship between physical, chemical and biological characteristics of drugs, dosage forms and drug action. DRUG Dissolution in body fluids Transported by fluids Traverse membranes Escape unwanted distribution Endure metabolic attack (1 st .pass effect) Penetrate in adequate conc. into sites of action Interact specifically Cause alteration of cellular function 2) ADME Studies a) Absorption, Distribution, Metabolism, Elimination b) Pharmacokinetics: studies the time course of drug concentration in the blood and tissues _rate and extent. c) ABSORPTION i) Dissolution of drug in fluids and entrance into the circulation. ii) Dissolution & absorption_ Ex: solid dosage form DISINTEGRATION: tablet/capsule into granules DEAGGREGATION: granules into fine particles WETTING: fine particles get wet DISSOLUTION : fine particles diffuse in liquid (diffusion layer: saturated layer of drug solution that envelops the surface of the solid drug particle); rate-limiting step . SOLUTION: drug in liquid form (acidic x basic medium). iii) Factors affecting rate of dissolution: (a) Surface area: inversely proportional to particle size (micronized powders)
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University of Wyoming PHCY 6100 Teixeira 2 (b)
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