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TABLETS-notes-2010 - University of Wyoming PHCY 6100 Solid...

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University of Wyoming PHCY 6100 Solid Dosage Forms: TABLETS 1. Def. Solid dosage forms prepared by compression or molding of powdered/granulated drugs and with the aid of suitable pharmaceutical excipients. 2. Characteristics: a) Most frequently prescribed commercial dosage form b) Stable, elegant and effective c) Convenient for handling, identification and administration d) Commercially available only in fixed dosage strengths e) Many formats (e.g. Valium® is triangular), sizes, colors, shapes (flat, convex), scored in halves, with elegant engravings, etc (determined by the format of die and punch used, by the amount of fill and amount of pressure applied to the fill). 3. Types a) Compressed Tablets : to be swallowed, made by single compression of all ingredients. b) Multiple Compressed Tablets : for separation of incompatible drugs or for modified release. Multiple-layered tablets: multiple feed and multiple compression of fill within a single die. Tablet-within-a-tablet: core tablet is placed precisely within the die for compression with surrounding fill. c) Sugar-coated tablets : Several layers of colored or uncolored sugar solution (sucrose, gelatin, acacia or PVP=polyvinylpyrrolidone) Time and expertise Final tablet may have an increase of up to 50 % of size and weight of uncoated tablet. Imprinting _ FDA 1995_ product-specific identification codes and distinctive symbols. Polishing: cloth or canvas impregnated with carnauba wax or beeswax or spraying with wax dissolved in acetone. Final tumbling with talc for high luster. d) Film-coated tablets : Thin layer of aqueous or non-aqueous polymer solution (plastic-like material): cellulose acetate phthalate; cellulose ether polymers. Protection, color, durability, less bulkiness, less time consuming. e) Gelatin-coated : capsule-shaped compressed tablet (caplets) f) Enteric coated tablets : Applied to whole tablet or to drug particles or granules: single or multiple layers Materials: shellac, phthalate derivatives 1
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