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UNIVERSITY OF WYOMING School of Pharmacy COURSE SYLLABUS PHCY 6100 – DOSE FORM DESIGN Fall 2010 Instructor Information: Instructor: M. Glaucia Teixeira [Tesh-áir-ah], PhD - Assoc. Professor of Pharmaceutics Phone: (307) 766-2690 E-mail: [email protected] Website: http://mgt.uwyo.edu Office: Health Sciences Bldg., Pharmacy, Rm.390 Office Hours: M, T, W, TR , 10-11:00 AM. Other times, check if I am available, or email/leave voice message for an appointment. Prerequisites: CHEM 2420 and 2440 . Course Description: Extensively introduces various types of dosage forms, discusses advantages and disadvantages of each and physicochemical principles involved in dose form stability. Introduction to the principles and technologies applied in the preparation of pharmaceutical dosage forms and drug delivery systems. Disability Statement: Students who have a physical, learning, or psychological disability and require accommodations, should let the instructor know as soon as possible. Students also must register with, and provide documentation of disability to the University Disability Support Services (UDSS), Rm. 330, Knight Hall, so accommodations are planned. Objectives/Outcomes/Standards Through an integrated way, students will gain an understanding of the interrelationships between physical pharmacy principles, biopharmaceutics and basic pharmacokinetics’ principles, dosage form design, product formulation, small- and large-scale product manufacturing, and clinical application of pharmaceuticals in patient care. Learning will also be integrated with and emphasized through laboratory exercises. After completing this course, the student should demonstrate competency in the following subjects: 1. Relationships between Drugs and Pharmacy 2. New Drug Development and Approval Processes (FDA) 3. Dosage Form Design: Biopharmaceutic and Pharmacokinetic considerations emphasizing ADME processes, bioavailability and bioequivalence, routes of drug administration and dosage regimen considerations. 4. Dosage Form Design: Formulation Considerations, Pharmaceutic Ingredients, and Current Good Manufacturing and Compounding Practices. 5. Peroral Solids: Powders, Granules, Capsules, Tablets, and Modified-Release Dosage Forms and Drug Delivery Systems 6. Oral Solutions, Syrups, and Elixirs; Topical solutions and Tinctures 7. Disperse Systems: Suspensions, Emulsions, Gels and Magmas Syllabus-PHCY6100-Teixeira –2010 1
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UNIVERSITY OF WYOMING School of Pharmacy 8. Aerosols, Inhalations, and Sprays 9. Parenteral Medications (SVP, LVP) and Sterile Fluids; pellets or implants; testing of parenterals for sterility, particulate matter, pyrogens, content and stability. 10. Products of Biotechnology and Biologics 11. Ointments, Creams, Pastes, Gels, Lotions 12. Transdermal Drug Delivery Systems 13. Ophthalmic, Nasal, Otic, and Oral Preparations Applied Topically 14. Suppositories and Other Rectal, Vaginal, and Urethral Preparations 15. Novel Dosage Forms and Drug Delivery Technologies.
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