Adrenal Gland Notes - The Adrenal 1 Anatomy of the cortex...

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Unformatted text preview: The Adrenal 1. Anatomy of the cortex and its hormones 1. Biosynthesis of the adrenal steroids 1. CRH-ACTH-cortisol 2. ACTH (and MSH) and skin color 3. Pathology of the adrenal Nelson’s Addison’s Cushing’s CAH 4. Aldosterone 5. Regulation of Blood Pressure Hypothalamo-Pituitary-Adrenal Axis Hypothalamus Pituitary Gland Adrenal Gland Anatomy Zona glomerulosa aldosterone Zona fasiculata (cells in bundles – fasicles ) corticoids Zona reticularis androgens The Adrenal 1. Anatomy of the cortex and its hormones 1. Biosynthesis of the adrenal steroids 1. CRH-ACTH-cortisol 2. ACTH (and MSH) and skin color 3. Pathology of the adrenal Nelson’s Addison’s Cushing’s CAH 4. Aldosterone 5. Regulation of Blood Pressure Biosynthesis of Adrenal Steroids • Hydrophobic cholesterol transferred to inner mitochondrial membrane by StAR ( st e ro ido g e nic a c ute r e g ula to ry) pro te in • S tAR s ynthe s is in g lo m e rulo s a induc e d b y Ang io te ns in II Biosynthesis !!!ENZYMES!!! P450 scc • So-called because light is maximally absorbed at 450nm when proteins are complexed with CO • scc = side chain cleavage enzyme • Genes coding for cy to c hro m e P 450 e nzym e s – a b b re via te d to CYP Bio s ynthe s is Ke y: G REEN (m ito c ho ndria PINK (S m o o th ER Testosterone precursor Ne xt pa g e Bio s ynthe s is Cortisol has a circadian rhythm How is this possible? Why is it important to know this? The Adrenal 1. Anatomy of the cortex and its hormones 2. Biosynthesis of the adrenal steroids 1. CRH-ACTH-cortisol 1. ACTH (and MSH) and skin color 2. Pathology of the adrenal Nelson’s Addison’s Cushing’s CAH 3. Aldosterone 4. Regulation of Blood Pressure CRH and ACTH corticotropes ACTH effects on Adrenal Stimulates synthesis and release of glucocorticoids and androgens via G s Immediately: • Increase cholesterol esterase • Increase StAR The Adrenal...
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Adrenal Gland Notes - The Adrenal 1 Anatomy of the cortex...

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