08 - CHAPTER 8 Carbohydrate Metabolism Biochemistry: The...

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Biochemistry: The Molecular Basis of Life, 4/e McKee/McKee Copyright © 2009 by Oxford University Press, Inc. C H A P T E R 8 Carbohydrate Metabolism
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FIGURE 8.1 Major Pathways in Carbohydrate Metabolism Overview Glucose as a major energy monosaccharide. Ancient pathways ! anoxic. Glycolysis [ ] ( Embden-Meyerhof-Parnas pathway ) = energy ( ATP ) generation process involving spliting of glucose (C 6 ) into two pyruvates (C 3 ) with concomitant formation of NADH . Glycolysis the archetype of a universal metabolic pathway; present in most modern organisms; one of the most ancient known metabolic pathways. Gluconeogenesis = glucose synthesis de novo. Glycogenesis = glycogen synthesis (glucose storage pathway). Pentose-P pathway = C 6 ! C 5 conversions. Pyruvate transformations. Citric acid cycle (Krebs cycle) (use of oxygen). Electron transport system (max glucose oxidation = max ATP). Links to biosinthesis (fatty acids, aa, nt)
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8.1 Glycolysis Energy generation (catabolism) – result of oxidation. Glycolysis – very inefficient (5% energy of glucose). C 6 H 12 O 6 + 2 ADP + 2 P i + 2 NAD + ! ! 2 C 3 H 3 O 3 + 2 ATP + 2 NADH + 2 H + + 2 H 2 O 2 steps: " substrate activation (spending ! ATP) " energy generation (oxidation, making ATP) 3 irreversible rxns, other – reversible ( Δ G°’ ~0) NADH – additional energy source (aerobic respiration) or liability (no oxygen). 10 enzymes of glycolysis (7 min): http://en.wikipedia.org/wiki/Glycolysis FIGURE 8.2 The Glycolytic Pathway
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FIGURE 8.3 Stage 1: Reactions of Glycolysis The reactions of the glycolytic pathway Step 1 1. Synthesis of glucose-6P. Spending ATP
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This note was uploaded on 10/15/2010 for the course MOLB 3610 taught by Professor Gomelsky during the Fall '10 term at Wyoming.

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08 - CHAPTER 8 Carbohydrate Metabolism Biochemistry: The...

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